Copy‐number analysis of Y‐linked loci in young men with non‐obstructive azoospermia: Implications for the rarity of early onset mosaic loss of chromosome Y
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12321
Abstract: Mosaic loss of chromosome Y (mLOY) is a common feature in elderly men. If mLOY can also occur in young men, it may lead to spermatogenic failure due to loss of spermatogenic genes. Indeed, previous… read more here.
Keywords: spermatogenic failure; mosaic loss; loss chromosome; young men ... See more keywords
Effects of polycyclic aromatic hydrocarbons and multiple metals co-exposure on the mosaic loss of chromosome Y in peripheral blood.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.125519
Abstract: Mosaic loss of chromosome Y (mLOY) is an indicator of genome instability, but the environmental stressors of mLOY remained largely unknown. In this study, we detected the internal exposure levels of 11 polycyclic aromatic hydrocarbon… read more here.
Keywords: mosaic loss; loss chromosome; blood; polycyclic aromatic ... See more keywords
Lack of age-related mosaic loss of W chromosome in long-lived birds
Sign Up to like & getrecommendations! Published in 2022 at "Biology Letters"
DOI: 10.1098/rsbl.2021.0553
Abstract: Females and males often exhibit different survival in nature, and it has been hypothesized that sex chromosomes may play a role in driving differential survival rates. For instance, the Y chromosome in mammals and the… read more here.
Keywords: mosaic loss; long lived; loss; age ... See more keywords
Mosaic loss of Y chromosome during aging
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DOI: 10.1126/science.add0839
Abstract: Description Spread of Y chromosome aneuploidy in myeloid cells with age promotes cardiac fibrosis During their lifetimes, organisms acquire somatic mutations in individual cells caused by genomic instability, endogenous DNA replication errors, or exposure to… read more here.
Keywords: mosaic loss; myeloid cells; chromosome; stem cells ... See more keywords
A funding mosaic for loss and damage
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DOI: 10.1126/science.adg5740
Abstract: In the context of climate policy, “loss and damage” refers to unavoided climate change impacts, including those from extreme weather events and slow-onset events such as sea-level rise, increasing temperatures, and loss of biodiversity. Some… read more here.
Keywords: mosaic loss; loss damage; loss; funding mosaic ... See more keywords
Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men's Health.
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DOI: 10.1152/physiol.00008.2023
Abstract: We present a brief introduction of loss of Y chromosome (LOY) in blood, and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we… read more here.
Keywords: mosaic loss; loss; blood; loss chromosome ... See more keywords