Viral RNA-dependent RNA polymerase mutants display an altered mutation spectrum resulting in attenuation in both mosquito and vertebrate hosts
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DOI: 10.1371/journal.ppat.1007610
Abstract: The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a severe reduction of number of virus particles and this occurs multiple times throughout the viral transmission cycle. Viral replication is… read more here.
Keywords: mosquito vertebrate; rna dependent; vertebrate hosts; attenuation ... See more keywords