Introduction to the special issue on: A new view of hippocampal area CA2
Sign Up to like & getrecommendations! Published in 2023 at "Hippocampus"
DOI: 10.1002/hipo.23514
Abstract: Who gets to define and name a brain area? Can we redefine or change it once a nomenclature is established? And must the definition apply to all species with said structure? When naming a structure,… read more here.
Keywords: definition; ca2; area; mossy fiber ... See more keywords
CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.071
Abstract: As a hallmark of epilepsy, mossy fiber sprouting was regarded as an ideal mode to study neural rewiring upon injury. The process of mossy fiber sprouting constitutes key steps for neural circuit formation, including axon… read more here.
Keywords: model epilepsy; fiber sprouting; mossy fiber; crmp2 ... See more keywords
Vesicle Pools of Memory at Mossy Fiber Synapses
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.07.005
Abstract: In this issue of Neuron, Vandael et al. (2020) reveal that post-tetanic potentiation at dentate gyrus mossy fiber synapses is induced by natural activity patterns. This plasticity is mediated by an increase in readily releasable vesicle… read more here.
Keywords: mossy fiber; vesicle pools; pools memory; fiber synapses ... See more keywords
Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23153-5
Abstract: The hippocampal mossy fiber synapse is a key synapse of the trisynaptic circuit. Post-tetanic potentiation (PTP) is the most powerful form of plasticity at this synaptic connection. It is widely believed that mossy fiber PTP… read more here.
Keywords: fiber; hippocampal mossy; mossy fiber; ptp ... See more keywords
Optogenetic stimulation of complex spatio-temporal activity patterns by acousto-optic light steering probes cerebellar granular layer integrative properties
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32017-w
Abstract: Optogenetics provides tools to control afferent activity in brain microcircuits. However, this requires optical methods that can evoke asynchronous and coordinated activity within neuronal ensembles in a spatio-temporally precise way. Here we describe a light… read more here.
Keywords: optogenetic stimulation; cerebellar granular; acousto optic; spatio temporal ... See more keywords
Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2108239118
Abstract: Significance Neurons have an exceptional capacity to grow axons and form synaptic circuits during development but not later life. In adults, the lack of circuit formation may support retention of skilled actions and memories but… read more here.
Keywords: mossy fiber; hippocampal mossy; adult; circuit formation ... See more keywords
Lacosamide modulates collapsin response mediator protein 2 and inhibits mossy fiber sprouting after kainic acid-induced status epilepticus
Sign Up to like & getrecommendations! Published in 2018 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001123
Abstract: Mossy fiber sprouting (MFS) and neuronal loss are important pathological features of chronic epilepsy closely related to the development of spontaneous recurrent seizures. However, the pathological mechanism of MFS remains unclear. Collapsin response mediator protein… read more here.
Keywords: protein; fiber sprouting; crmp2; status epilepticus ... See more keywords
Increased vesicle fusion competence underlies long-term potentiation at hippocampal mossy fiber synapses
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.add3616
Abstract: Presynaptic long-term potentiation (LTP) is thought to play an important role in learning and memory. However, the underlying mechanism remains elusive because of the difficulty of direct recording during LTP. Hippocampal mossy fiber synapses exhibit… read more here.
Keywords: long term; ltp; mossy fiber; hippocampal mossy ... See more keywords
Female-specific synaptic dysfunction and cognitive impairment in a mouse model of PCDH19 disorder
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.aaz3893
Abstract: More is not always better Mutations in X-linked genes usually affect male individuals more than females, but the opposite characterizes the Protocadherin-19 gene (PCDH19) on the X chromosome. Mutations in the PCDH19 cell-adhesion molecule cause… read more here.
Keywords: mossy fiber; pcdh19; mice; pcdh19 disorder ... See more keywords
Separable actions of acetylcholine and noradrenaline on neuronal ensemble formation in hippocampal CA3 circuits
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009435
Abstract: In the hippocampus, episodic memories are thought to be encoded by the formation of ensembles of synaptically coupled CA3 pyramidal cells driven by sparse but powerful mossy fiber inputs from dentate gyrus granule cells. The… read more here.
Keywords: separable actions; ensemble formation; mossy fiber; formation ... See more keywords
Modeling analysis of subthreshold voltage signaling along hippocampal mossy fiber axons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.966636
Abstract: Axons are classically thought of as electrically well isolated from other parts of the neurons due to the shape of a long cable-like structure. In contrast to this classical view on axonal compartmentalization, recent studies… read more here.
Keywords: calcium; subthreshold voltage; voltage signaling; voltage ... See more keywords