M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06990-9
Abstract: The primary cilium is elongated from the mother centriole and has diverse signaling roles during development and disease. The CP110-CEP97 complex functions as a negative regulator of ciliogenesis, although the mechanisms regulating its mother centriole… read more here.
Keywords: ciliogenesis; localization; mother centriole; cp110 cep97 ... See more keywords
Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.04.04.486992
Abstract: Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by PCM1. To study the requirement for centriolar satellites, we generated mice lacking PCM1. Pcm1−/− mice display partially penetrant perinatal lethality with survivors exhibiting hydrocephalus,… read more here.
Keywords: ciliogenesis; centriolar satellites; mother centriole; expedite mother ... See more keywords
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.
Sign Up to like & getrecommendations! Published in 2023 at "EMBO reports"
DOI: 10.15252/embr.202256317
Abstract: Primary cilia are sensory organelles that coordinate diverse signaling pathways, controlling development and homeostasis. Progression beyond the early steps of ciliogenesis requires the removal of a distal end protein, CP110, from the mother centriole, a… read more here.
Keywords: herc2; ciliogenesis; mother centriole; cp110 ubiquitination ... See more keywords