Motif-based spectral clustering of weighted directed networks
Sign Up to like & getrecommendations! Published in 2020 at "Applied Network Science"
DOI: 10.1007/s41109-020-00293-z
Abstract: Clustering is an essential technique for network analysis, with applications in a diverse range of fields. Although spectral clustering is a popular and effective method, it fails to consider higher-order structure and can perform poorly… read more here.
Keywords: spectral clustering; based spectral; directed networks; clustering weighted ... See more keywords
Elucidation of Short Linear Motif-Based Interactions of the FERM Domains of Ezrin, Radixin, Moesin, and Merlin.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.3c00096
Abstract: The ERM (ezrin, radixin, and moesin) family of proteins and the related protein merlin participate in scaffolding and signaling events at the cell cortex. The proteins share an N-terminal FERM [band four-point-one (4.1) ERM] domain… read more here.
Keywords: motif based; short linear; radixin moesin; ezrin radixin ... See more keywords
Proteome‐wide analysis of phospho‐regulated PDZ domain interactions
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DOI: 10.15252/msb.20178129
Abstract: A key function of reversible protein phosphorylation is to regulate protein–protein interactions, many of which involve short linear motifs (3–12 amino acids). Motif‐based interactions are difficult to capture because of their often low‐to‐moderate affinities. Here,… read more here.
Keywords: motif based; phospho; domain interactions; phosphorylation ... See more keywords
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular systems biology"
DOI: 10.15252/msb.202211164
Abstract: Phosphorylation is a ubiquitous post-translation modification that regulates protein function by promoting, inhibiting or modulating protein-protein interactions. Hundreds of thousands of phosphosites have been identified but the vast majority have not been functionally characterised and… read more here.
Keywords: large scale; phospho modulated; motif based; protein interactions ... See more keywords
Motif-based Graph Representation Learning with Application to Chemical Molecules
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DOI: 10.48550/arxiv.2208.04529
Abstract: This work considers the task of representation learning on the attributed relational graph (ARG). Both the nodes and edges in an ARG are associated with attributes/features allowing ARGs to encode rich structural information widely observed… read more here.
Keywords: local structural; representation learning; motif based; graph representation ... See more keywords