Targeting a KRAS i‐motif forming sequence by unmodified and gamma‐modified peptide nucleic acid oligomers
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DOI: 10.1002/bip.23529
Abstract: Growing interest in i‐motif DNA as a transcriptional regulatory element motivates development of synthetic molecules capable of targeting these structures. In this study, we designed unmodified peptide nucleic acid (PNA) and gamma‐modified PNA (γPNA) oligomers… read more here.
Keywords: spectroscopy; motif forming; pna pna; sequence ... See more keywords
Rapid Screen of Potential i-Motif Forming Sequences in DNA Repair Gene Promoters
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DOI: 10.1021/acsomega.8b01551
Abstract: We have studied the in vitro stability of 25 potential i-motif-forming DNA sequences found within the promoter regions of 18 different human DNA repair genes. Three widely available methods of characterization were used to rapidly… read more here.
Keywords: motif; potential motif; motif forming; dna repair ... See more keywords