Glycosylation site Asn168 is important for slow in vivo clearance of recombinant human diamine oxidase heparin-binding motif mutants.
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DOI: 10.1093/glycob/cwab122
Abstract: Elevated plasma and tissues histamine concentrations can cause severe symptoms in mast cell activation syndrome, mastocytosis or anaphylaxis. Endogenous and recombinant human diamine oxidase (rhDAO) can rapidly and completely degrade histamine, and administration of rhDAO… read more here.
Keywords: clearance; binding motif; motif mutants; diamine oxidase ... See more keywords