Microridge-like structures anchor motile cilia.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29741-3
Abstract: Several tissues contain cells with multiple motile cilia that generate a fluid or particle flow to support development and organ functions; defective motility causes human disease. Developmental cues orient motile cilia, but how cilia are… read more here.
Keywords: actin; like structures; structures anchor; microridge like ... See more keywords
Strain-specific differences in brain gene expression in a hydrocephalic mouse model with motile cilia dysfunction
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31743-5
Abstract: Congenital hydrocephalus results from cerebrospinal fluid accumulation in the ventricles of the brain and causes severe neurological damage, but the underlying causes are not well understood. It is associated with several syndromes, including primary ciliary… read more here.
Keywords: motile cilia; dysfunction; expression; brain ... See more keywords
The transcriptional signature associated with human motile cilia
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66453-4
Abstract: Cilia are complex microtubule-based organelles essential to a range of processes associated with embryogenesis and tissue homeostasis. Mutations in components of these organelles or those involved in their assembly may result in a diverse set… read more here.
Keywords: motile cilia; signature; transcriptional signature; cilia associated ... See more keywords
Tau tubulin kinase is required for spermatogenesis and development of motile cilia in planarian flatworms
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-10-0663
Abstract: Cilia are microtubule-based structures that protrude from the apical surface of cells to mediate motility, transport, intracellular signaling, and environmental sensing. Tau tubulin kinases (TTBKs) destabilize microtubules by phosphorylating microtubule-associated proteins (MAPs) of the MAP2/Tau… read more here.
Keywords: smed ttbk; tau tubulin; development; motile cilia ... See more keywords
Plastic loss of motile cilia in the gills of Polypterus in response to high CO2 or terrestrial environments
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1101/2022.04.06.487418
Abstract: The evolutionary transition of vertebrates from water to land during the Devonian period was accompanied by major changes in animal respiratory systems in terms of physiology and morphology. Indeed, the fossil record of the early… read more here.
Keywords: motile cilia; cilia gills; high co2; gills polypterus ... See more keywords
Cell cycle proteins moonlight in multiciliogenesis
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DOI: 10.1126/science.aaq0770
Abstract: Proteins that control cell cycle progression also drive multiciliated cell differentiation Multiciliated cells (MCCs) are a specialized population of postmitotic cells that are decorated with tens to hundreds of hairlike protrusions, termed motile cilia, that… read more here.
Keywords: cycle proteins; motile cilia; proteins moonlight; cell cycle ... See more keywords
Motile Cilia on Kidney Proximal Tubular Epithelial Cells Are Associated With Tubular Injury and Interstitial Fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.765887
Abstract: It is well established that mammalian kidney epithelial cells contain a single non-motile primary cilium (9 + 0 pattern). However, we noted the presence of multiple motile cilia with a central microtubular pair (9 +… read more here.
Keywords: motile cilia; tubular injury; injury; kidney ... See more keywords
Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineering"
DOI: 10.3390/bioengineering9090421
Abstract: Motile cilia are hair-like microscopic structures which generate directional flow to provide fluid transport in various biological processes. Ciliary beating is one of the sources of cerebrospinal flow (CSF) in brain ventricles. In this study,… read more here.
Keywords: cerebrospinal flow; motile cilia; brain; brain ventricles ... See more keywords
Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22168361
Abstract: Zebrafish is a vertebrate teleost widely used in many areas of research. As embryos, they develop quickly and provide unique opportunities for research studies owing to their transparency for at least 48 h post fertilization.… read more here.
Keywords: zebrafish motile; motile cilia; primary ciliary; ciliary dyskinesia ... See more keywords
PCD Genes—From Patients to Model Organisms and Back to Humans
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031749
Abstract: Primary ciliary dyskinesia (PCD) is a hereditary genetic disorder caused by the lack of motile cilia or the assembxly of dysfunctional ones. This rare human disease affects 1 out of 10,000–20,000 individuals and is caused… read more here.
Keywords: patients model; motile cilia; model organisms; organisms back ... See more keywords