Factors associated with motor complications in Parkinson's disease
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DOI: 10.1002/brb3.837
Abstract: Levodopa is the most effective therapy for treating Parkinson's disease (PD); however, side effects such as dyskinesias and motor fluctuations may occur after some years of its usage. The aims of this study were to… read more here.
Keywords: motor complications; factors associated; complications parkinson; motor ... See more keywords
Motor Complications in Parkinson's Disease: Results from 3343 Patients Followed for up to 12 Years
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DOI: 10.1002/mdc3.14044
Abstract: Motor complications are well recognized in Parkinson's disease (PD), but their reported prevalence varies and functional impact has not been well studied. read more here.
Keywords: parkinson disease; motor complications; disease results; complications parkinson ... See more keywords
Levodopa: A new look at an old friend
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27216
Abstract: Levodopa is the most effective antiparkinsonian agent, but chronic treatment is associated with the development of motor complications in the majority of patients with PD. Recent scientific and clinical advances are improving this situation. Long‐term,… read more here.
Keywords: look old; motor complications; levodopa new; new look ... See more keywords
Motor complications in Parkinson's disease: 13‐year follow‐up of the CamPaIGN cohort
Sign Up to like & getrecommendations! Published in 2020 at "Movement Disorders"
DOI: 10.1002/mds.27882
Abstract: Long‐term population‐representative data on motor fluctuations and levodopa‐induced dyskinesias in Parkinson's disease is lacking. read more here.
Keywords: motor complications; year follow; complications parkinson; disease year ... See more keywords
Benign versus malignant Parkinson disease: the unexpected silver lining of motor complications
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-09954-6
Abstract: Objective We sought to evaluate demographic, clinical, and habits/occupational variables between phenotypic extremes in Parkinson’s disease (PD). Methods Databases from nine movement disorders centers across seven countries were retrospectively searched for subjects meeting criteria for… read more here.
Keywords: motor complications; habits occupational; parkinson disease; mpd ... See more keywords
Risk factors for motor complications in female patients with Parkinson’s disease
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DOI: 10.1007/s10072-022-05959-3
Abstract: To investigate the risk factors of motor complications in female patients with Parkinson’s disease (PD) and the correlation between the occurrence of motor complications and sex hormone levels. According to the occurrence and types of… read more here.
Keywords: motor complications; wearing phenomenon; female patients; risk factors ... See more keywords
Safety and efficacy of unilateral focused ultrasound pallidotomy on motor complications in Parkinson’s disease (PD): a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2024 at "Neurological Sciences"
DOI: 10.1007/s10072-024-07617-2
Abstract: To systematically review and conduct a meta-analysis to evaluate the safety and efficacy of the unilateral focused ultrasound (FUS) pallidotomy on motor complications in Parkinson’s disease (PD) patients. A comprehensive search strategy was implemented through… read more here.
Keywords: meta analysis; analysis; unilateral focused; motor complications ... See more keywords
New dopaminergic therapies for PD motor complications
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108869
Abstract: BACKGROUND Motor complications, characterized by "off" periods - when anti-parkinsonian medications are ineffective - and dyskinesia, are the hallmark of advanced Parkinson's disease (PD). While levodopa is the gold standard PD medication in terms of… read more here.
Keywords: motor complications; new dopaminergic; dopaminergic therapies; motor ... See more keywords
The role of genetic factors in the occurrence of levodopa-induced motor complications in Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2025 at "Neurological research"
DOI: 10.1080/01616412.2025.2528974
Abstract: BACKGROUND The genetic contribution to the development of levodopa-induced motor complications in Parkinson's disease (PD) remains poorly understood. OBJECTIVES We aimed to investigate the association between selected polymorphisms of the catechol-O-methyltransferase (COMT), dopamine receptor D2… read more here.
Keywords: disease; induced motor; motor complications; levodopa induced ... See more keywords
Opicapone as adjunct to levodopa in treated Parkinson's disease without motor complications: A randomized clinical trial
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Neurology"
DOI: 10.1111/ene.16420
Abstract: Catechol‐O‐methyl transferase (COMT) inhibitors are routinely used to manage motor fluctuations in Parkinson's disease (PD). We assessed the effect of opicapone on motor symptom severity in levodopa‐treated patients without motor complications. read more here.
Keywords: levodopa treated; motor complications; without motor; motor ... See more keywords
Recent Advances in Drug Therapy for Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2022 at "Internal Medicine"
DOI: 10.2169/internalmedicine.8940-21
Abstract: Parkinson's disease (PD) is a neurodegenerative disease manifesting with motor and non-motor symptoms. Current treatment mainly relies on medication as a symptomatic therapy modulating neurotransmitters. Dopamine replacement therapy has been established, and levodopa is the… read more here.
Keywords: disease; parkinson disease; therapy; motor complications ... See more keywords