DREADD Activation of Pedunculopontine Cholinergic Neurons Reverses Motor Deficits and Restores Striatal Dopamine Signaling in Parkinsonian Rats
Sign Up to like & getrecommendations! Published in 2020 at "Neurotherapeutics"
DOI: 10.1007/s13311-019-00830-4
Abstract: The brainstem-based pedunculopontine nucleus (PPN) traditionally associates with motor function, but undergoes extensive degeneration during Parkinson’s disease (PD), which correlates with axial motor deficits. PPN-deep brain stimulation (DBS) can alleviate certain symptoms, but its mechanism(s)… read more here.
Keywords: ppn; cholinergic neurons; dopamine; striatal dopamine ... See more keywords
Apoferritin improves motor deficits in MPTP-treated mice by regulating brain iron metabolism and ferroptosis
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102431
Abstract: Summary Iron deposition is one of the key factors in the etiology of Parkinson's disease (PD). Iron-free-apoferritin has the ability to store iron by combining with a ferric hydroxide-phosphate compound to form ferritin. In this… read more here.
Keywords: mptp induced; ferroptosis; iron; apoferritin ... See more keywords
Ahr and Cyp1a2 genotypes both affect susceptibility to motor deficits following gestational and lactational exposure to polychlorinated biphenyls
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.01.008
Abstract: HighlightsGenetic variation in the aryl hydrocarbon receptor and cytochrome P450 1A2 (CYP1A2) alter sensitivity to developmental PCB exposure.PCB‐treated high‐affinity Ahrb mice had greater deficits in motor function tests associated with nigrostriatal pathways.PCB‐treated Cyp1a2(−/−) knockout mice… read more here.
Keywords: exposure; pcb; motor; mice ... See more keywords
Does L4/5 Pose Additional Neurologic Risk in Lateral Lumbar Interbody Fusion?
Sign Up to like & getrecommendations! Published in 2019 at "World neurosurgery"
DOI: 10.1016/j.wneu.2019.05.144
Abstract: PURPOSE Lateral lumbar interbody fusion (LLIF) at the L4/5 level is a controversial topic in the spine literature. The aim of this study was to compare the rate of nerve-related motor deficits in patients undergoing… read more here.
Keywords: risk; new motor; lateral lumbar; motor ... See more keywords
Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2213093120
Abstract: Significance Dopamine (DA) is critical for movements, and its loss causes debilitating motor deficits in Parkinson’s disease (PD). However, dopamine is also strongly implicated in reward learning. Here, we used two distinct motor tasks to… read more here.
Keywords: parkinsonian motor; motor deficits; critically drives; motor ... See more keywords
Associations between tactile localization and motor function in children with motor deficits
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Developmental Disabilities"
DOI: 10.1080/20473869.2016.1278316
Abstract: Children with developmental disorders often have poor motor performance. This study aimed to address the association between tactile localization ability, an indicator of body image, and motor function in children with motor deficits. Eighteen children… read more here.
Keywords: tactile localization; motor function; children motor; motor ... See more keywords
Neurological, nutritional and alcohol consumption factors underlie cognitive and motor deficits in chronic alcoholism
Sign Up to like & getrecommendations! Published in 2019 at "Addiction Biology"
DOI: 10.1111/adb.12584
Abstract: Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional… read more here.
Keywords: cognitive motor; alcohol consumption; alcoholism; neurological nutritional ... See more keywords
Abstract TP106: Automated Assessment of Behavioral Function After Experimental Stroke
Sign Up to like & getrecommendations! Published in 2020 at "Stroke"
DOI: 10.1161/str.51.suppl_1.tp106
Abstract: Introduction: Manual scoring of behavior tests is commonly used for assessing motor deficits after stroke, however, it is labor intensive and subject to bias. These limitations lead to inconsistent assessment between research groups and non-reproducible… read more here.
Keywords: mice; stroke; motor deficits; motor ... See more keywords
Appraising The Evidence for Conservative versus Surgical Management of Motor Deficits in Degenerative Cervical Radiculopathy
Sign Up to like & getrecommendations! Published in 2022 at "Global Spine Journal"
DOI: 10.1177/21925682221109562
Abstract: Study Design Systematic review. Objectives Understanding the prevalence and outcome of motor deficits in degenerative cervical radiculopathy is important to guide management. We compared motor radiculopathy outcomes after conservative and surgical management, a particular focus… read more here.
Keywords: motor deficits; deficits degenerative; management; motor ... See more keywords
Inhibition of colony-stimulating factor 1 receptor early in disease ameliorates motor deficits in SCA1 mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-017-0880-z
Abstract: BackgroundPolyglutamine (polyQ) expansion in the protein Ataxin-1 (ATXN1) causes spinocerebellar ataxia type 1 (SCA1), a fatal dominantly inherited neurodegenerative disease characterized by motor deficits, cerebellar neurodegeneration, and gliosis. Currently, there are no treatments available to… read more here.
Keywords: disease; motor; sca1 mice; factor ... See more keywords
Surgery for Epilepsy Involving Rolandic and Perirolandic Cortex: A Case Series Assessing Complications and Efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Operative Neurosurgery"
DOI: 10.1227/ons.0000000000000324
Abstract: BACKGROUND: Surgical removal of lesions around the rolandic cortex remains a challenge for neurosurgeons owing to the high risk of neurological deficits. Evaluating the risk factors associated with motor deficits after surgery in this region… read more here.
Keywords: motor deficits; bank; motor; cortex ... See more keywords