Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2016.4703
Abstract: Importance Catechol O-methyltransferase (COMT) inhibitors are an established treatment for end-of-dose motor fluctuations associated with levodopa therapy in patients with Parkinson disease (PD). Current COMT inhibitors carry a high risk for toxic effects to hepatic… read more here.
Keywords: phase; opicapone; treatment; time ... See more keywords
Frequency of mood and anxiety fluctuations in Parkinson's disease patients with motor fluctuations: A systematic review
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27465
Abstract: After 5 years of treatment with levodopa, approximately 40% to 50% of patients with Parkinson's disease (PD) develop motor complications such as dyskinesias or motor fluctuations. These are often accompanied by nonmotor fluctuations, such as… read more here.
Keywords: patients motor; anxiety; frequency; motor fluctuations ... See more keywords
Long-term safety and efficacy of opicapone in Japanese Parkinson’s patients with motor fluctuations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-021-02315-1
Abstract: The double-blind part of the COMFORT-PD (COMt-inhibitor Findings from Opicapone Repeated Treatment for Parkinson’s Disease) study in Japanese levodopa-treated patients with Parkinson’s disease and motor fluctuations found that both opicapone 25 and 50 mg were… read more here.
Keywords: long term; safety; time; motor fluctuations ... See more keywords
Accuracy of MDS-UPDRS section IV for detecting motor fluctuations in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Neurological Sciences"
DOI: 10.1007/s10072-019-03745-2
Abstract: BackgroundIn a precedent paper, we validated part IV of the Unified Parkinson’s Disease Rating Scale (UPDRS) for detecting motor fluctuations in Parkinson’s Disease (PD) patients using a 12-h Waking-Day Motor Assessment (WDMA) as gold standard,… read more here.
Keywords: mds updrs; motor; motor fluctuations; parkinson disease ... See more keywords
COMT Inhibitors in the Management of Parkinson's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "CNS drugs"
DOI: 10.1007/s40263-021-00888-9
Abstract: Levodopa treatment remains the gold standard for Parkinson's disease, but shortcomings related to the pharmacological profile, notably, oral administration and the consequent occurrence of motor complications, have led to the development of several add-on levodopa… read more here.
Keywords: motor fluctuations; min day; parkinson disease; motor ... See more keywords
Ambulatory surface electromyography with accelerometry for evaluating daily motor fluctuations in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Neurophysiology"
DOI: 10.1016/j.clinph.2020.11.039
Abstract: OBJECTIVE To evaluate motor fluctuations in patients with advanced Parkinson's disease (PD) using a small-sized wearable device for surface electromyography (EMG) with accelerometry (ACC) for 24 hours. METHODS Seven PD patients with medication were measured… read more here.
Keywords: surface electromyography; motor; motor fluctuations; parkinson disease ... See more keywords
Adoption (early levodopa with opicapone in Parkinson's patients with motor fluctuations) study in Parkinson's disease: Design and rationale of a randomized prospective, open-label exploratory trial
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2021.119423
Abstract: Background and aims: Opicapone (OPC) proved to be effective in the treatment of end-of-dose motor fluctuations in Parkinson's disease (PD) patients. About 80–100% of PD patients show some degree of wearing-off within 10 years of… read more here.
Keywords: open label; motor fluctuations; dopa; parkinson disease ... See more keywords
Prospective evaluation of pulmonary function in Parkinson's disease patients with motor fluctuations
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2016.1194274
Abstract: Background. Spirometry patterns suggesting restrictive and obstructive pulmonary dysfunction have been reported in Parkinson’s disease (PD). However, the patterns’ precise relation to PD pathophysiology remains unclear. Purpose/Aim. To assess ON- versus OFF-state pulmonary function, the… read more here.
Keywords: state; patients motor; spirometry; pulmonary function ... See more keywords
Benefit of long-acting paliperidone in Huntington's disease: a case report.
Sign Up to like & getrecommendations! Published in 2021 at "International Clinical Psychopharmacology"
DOI: 10.1097/yic.0000000000000346
Abstract: Through this brief report, we described our clinical considerations about the treatment of motor fluctuations and psychiatric comorbidities in Huntington's disease, for example, aggressiveness and obsessive-compulsive disorders. Indeed, as classical treatment, for example, olanzapine and… read more here.
Keywords: report; huntington disease; motor fluctuations; motor ... See more keywords
Opicapone Use in Clinical Practice across Germany: A Sub-Analysis of the OPTIPARK Study in Parkinson’s Disease Patients with Motor Fluctuations
Sign Up to like & getrecommendations! Published in 2022 at "European Neurology"
DOI: 10.1159/000523771
Abstract: Introduction: The OPTIPARK study confirmed the effectiveness and safety of opicapone as adjunct therapy to levodopa in patients with Parkinson’s disease (PD) and motor fluctuations under real-world conditions. The aim of this sub-analysis was to… read more here.
Keywords: parkinson disease; clinical practice; sub analysis; motor fluctuations ... See more keywords
Opicapone versus placebo in the treatment of Parkinson’s disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN (OpiCapone Effect on motor fluctuations and pAiN) trial
Sign Up to like & getrecommendations! Published in 2022 at "BMC Neurology"
DOI: 10.1186/s12883-022-02602-8
Abstract: Background Optimisation of dopaminergic therapy may alleviate fluctuation-related pain in Parkinson’s disease (PD). Opicapone (OPC) is a third-generation, once-daily catechol-O-methyltransferase inhibitor shown to be generally well tolerated and efficacious in reducing OFF-time in two pivotal… read more here.
Keywords: motor fluctuations; pain; treatment; patients end ... See more keywords