Small sensory spinal lesions that affect hand function in monkeys greatly alter primary afferent and motor neuron connections in the cord
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25395
Abstract: Small sensory spinal injuries induce plasticity across the neuraxis, but little is understood about their effect on segmental connections or motor neuron (MN) function. Here, we begin to address this at two levels. First, we… read more here.
Keywords: function; small sensory; motor; motor neuron ... See more keywords
Survival motor neuron protein deficiency alters microglia reactivity
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24177
Abstract: Survival motor neuron (SMN) protein deficiency results in loss of alpha motor neurons and subsequent muscle atrophy in patients with spinal muscular atrophy (SMA). Reactive microglia have been reported in SMA mice and depleting microglia… read more here.
Keywords: survival motor; protein deficiency; sma; motor ... See more keywords
Intracerebroventricular Delivery in Mice for Motor Neuron Diseases.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6817-6_19
Abstract: The use of antisense oligonucleotides to target specific mRNA sequences represents a promising therapeutic strategy for neurological disorders. Recent advances in antisense technology enclose the development of phosphorodiamidate morpholino oligomers (MO), which is one of… read more here.
Keywords: neuron diseases; delivery; motor neuron; mice ... See more keywords
Motor neuron involvement in anti-Ma2-associated paraneoplastic neurological syndrome
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurology"
DOI: 10.1007/s00415-018-9143-x
Abstract: ObjectiveTo present clinical, radiological, and pathological features of a cohort of patients with motor neuron involvement in association with anti-Ma2 antibodies (Ma2-Ab).MethodsRetrospective case-series of patients with definite paraneoplastic neurological syndrome (PNS) and Ma2-Ab, and cases… read more here.
Keywords: ma2; neuron involvement; syndrome; motor neuron ... See more keywords
GGC repeat expansions in NOTCH2NLC causing a phenotype of lower motor neuron syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurology"
DOI: 10.1007/s00415-022-11092-0
Abstract: A genetic diagnosis cannot be made in a considerable proportion of patients with hereditary lower motor neuron (LMN) syndromes. The GGC repeat expansion in the 5′untranslated region (5′UTR) of NOTCH2NLC gene has been reported to… read more here.
Keywords: ggc repeat; phenotype; lower motor; ggc ... See more keywords
Generalized lower motor neuron paralysis associated with Toxocara canis in a husky puppy
Sign Up to like & getrecommendations! Published in 2017 at "Comparative Clinical Pathology"
DOI: 10.1007/s00580-017-2486-3
Abstract: Toxocara canis is a parasitic, ascarid nematode considered to be one of the most prevalent gastrointestinal helminths of domestic dogs and other canids worldwide. The larvae of this parasite in dogs migrate to the lungs… read more here.
Keywords: motor neuron; neuron paralysis; lower motor; paralysis ... See more keywords
Comments on “Camptocormia as presenting in lower motor neuron disease with TARDBP mutation: case report”
Sign Up to like & getrecommendations! Published in 2017 at "Neurological Sciences"
DOI: 10.1007/s10072-017-3060-0
Abstract: Recently, Camptocormia raised some interest as a motor neuron disease symptom as shown in a recent letter [1]. We read on the Neurological Sciences journal that piece, entitled BCamptocormia as presenting in lower motor neuron… read more here.
Keywords: neuron disease; motor neuron; case report;
A Docosahexaenoic Acid-Derived Pro-resolving Agent, Maresin 1, Protects Motor Neuron Cells Death
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2556-1
Abstract: Maresin 1 is a novel pro-resolving mediator derived from docosahexaenoic acid (DHA), with potent anti-inflammation effects against several animal models, including brain ischemia, sepsis, and lung fibrosis. However, its effect against motor neuron cell death… read more here.
Keywords: death; pro resolving; motor neuron; stress ... See more keywords
Time Is Motor Neuron: Therapeutic Window and Its Correlation with Pathogenetic Mechanisms in Spinal Muscular Atrophy
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0831-9
Abstract: Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by the degeneration of lower motor neurons (MNs) in the spinal cord and brain stem, which results in relentless muscle weakness and wasting, leading… read more here.
Keywords: window; spinal muscular; motor neuron; motor ... See more keywords
Autophagy in motor neuron diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2020.03.009
Abstract: Motor neuron diseases (MNDs) are a wide group of neurodegenerative disorders characterized by the degeneration of a specific neuronal type located in the central nervous system, the motor neuron (MN). There are two main types… read more here.
Keywords: autophagy motor; motor neuron; neuron diseases; motor ... See more keywords
Fazio-Londe syndrome in siblings from India with different phenotypes
Sign Up to like & getrecommendations! Published in 2018 at "Brain and Development"
DOI: 10.1016/j.braindev.2018.02.010
Abstract: BACKGROUND Fazio-Londe syndrome also called progressive bulbar palsy of childhood is a very rare motor neuron disease of pediatric age group characterized by progressive paralysis of lower cranial nerves. OBJECTIVE To describe Fazio-Londe syndrome in… read more here.
Keywords: fazio londe; motor neuron; syndrome siblings; palsy ... See more keywords