Quantitative comparison of the mRNA content of human iPSC‐derived motor neurons and their extracellular vesicles
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13059
Abstract: Extracellular vesicles (EVs) contain various cargo molecules, including RNAs and proteins. EVs, which include exosomes, are predicted to be suitable surrogates of their source cells for liquid biopsy to measure biomarkers. Several studies have performed… read more here.
Keywords: extracellular vesicles; motor neurons; mrna content; motor ... See more keywords
Mouse embryonic stem cell‐derived motor neurons are susceptible to ferroptosis
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13545
Abstract: Ferroptosis is a regulated form of cell death driven by the lethal accumulation of lipid peroxides in cell membranes. Several regulators of ferroptosis have been identified using cancer cell lines. However, the cellular pathways of… read more here.
Keywords: cell; motor neurons; stem cell; ferroptosis ... See more keywords
In Vitro Modeling of Nerve–Muscle Connectivity in a Compartmentalized Tissue Culture Device
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Biosystems"
DOI: 10.1002/adbi.201800307
Abstract: Motor neurons project axons from the hindbrain and spinal cord to muscle, where they induce myofibre contractions through neurotransmitter release at neuromuscular junctions. Studies of neuromuscular junction formation and homeostasis have been largely confined to… read more here.
Keywords: motor neurons; muscle; nerve muscle; motor ... See more keywords
Actuating Extracellular Matrices Decouple the Mechanical and Biochemical Effects of Muscle Contraction on Motor Neurons
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202403712
Abstract: Emerging in vivo evidence suggests that repeated muscle contraction, or exercise, impacts peripheral nerves. However, the difficulty of isolating the muscle‐specific impact on motor neurons in vivo, as well as the inability to decouple the… read more here.
Keywords: muscle contraction; muscle; effects muscle; motor neurons ... See more keywords
TARDBP (TDP-43) Knock-in Zebrafish Display a Late-Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons.
Sign Up to like & getrecommendations! Published in 2025 at "Annals of neurology"
DOI: 10.1002/ana.78012
Abstract: OBJECTIVE Mutations in TARDBP (encoding TDP-43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.… read more here.
Keywords: spinal cord; cord motor; tdp; motor ... See more keywords
Oxidative stress disrupts the cytoskeleton of spinal motor neurons
Sign Up to like & getrecommendations! Published in 2022 at "Brain and Behavior"
DOI: 10.1002/brb3.2870
Abstract: Traumatic spinal cord injury (SCI) is a common and devastating central nervous disease, the treatment of which faces many challenges to the medical community and society as a whole. Treatment measures based on oxidative stress… read more here.
Keywords: stress spinal; motor neurons; oxidative stress; spinal motor ... See more keywords
Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-03792-z
Abstract: Transactive response DNA-binding protein 43 kDa (TDP-43) encoded by the TARDBP gene is an evolutionarily conserved heterogeneous nuclear ribonucleoprotein (hnRNP) that regulates multiple steps of RNA metabolism, and its cytoplasmic aggregation characterizes degenerating motor neurons… read more here.
Keywords: multi phaseted; vulnerability als; motor neurons; vulnerability ... See more keywords
Insights into the identification of a molecular signature for amyotrophic lateral sclerosis exploiting integrated microRNA profiling of iPSC-derived motor neurons and exosomes
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-022-04217-1
Abstract: Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder characterized by progressive degeneration of motor neurons (MNs). Most cases are sporadic, whereas 10% are familial. The pathological mechanisms underlying the disease are partially understood, but… read more here.
Keywords: lateral sclerosis; ipsc derived; amyotrophic lateral; motor neurons ... See more keywords
Motor imagery while viewing self-finger movements facilitates the excitability of spinal motor neurons
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Brain Research"
DOI: 10.1007/s00221-020-05870-3
Abstract: Action observation (AO) and motor imagery (MI) are potential methods to improve various motor functions. AO and MI facilitate corticospinal excitability. Additionally, the combination of AO and MI (AO + MI) facilitates greater corticospinal excitability than AO… read more here.
Keywords: motor imagery; motor neurons; spinal motor; motor ... See more keywords
ALS-CSF-induced structural changes in spinal motor neurons of rat pups cause deficits in motor behaviour
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Brain Research"
DOI: 10.1007/s00221-020-05969-7
Abstract: Amyotrophic lateral sclerosis (ALS) is a late-onset, neurodegenerative disease associated with the loss of motor neurons in the spinal cord, brain stem and primary motor cortex. Deficit in the motor function is one of the… read more here.
Keywords: als csf; motor neurons; lumbar; motor ... See more keywords
Nucleo-cytoplasmic transport of TDP-43 studied in real time: impaired microglia function leads to axonal spreading of TDP-43 in degenerating motor neurons
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neuropathologica"
DOI: 10.1007/s00401-018-1875-2
Abstract: Transactivating DNA-binding protein-43 (TDP-43) deposits represent a typical finding in almost all ALS patients, more than half of FTLD patients and patients with several other neurodegenerative disorders. It appears that perturbation of nucleo-cytoplasmic transport is… read more here.
Keywords: tdp; motor neurons; transport; nucleo cytoplasmic ... See more keywords