How Well Do Rodent Models of Parkinson’s Disease Recapitulate Early Non-Motor Phenotypes? A Systematic Review
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DOI: 10.3390/biomedicines10123026
Abstract: The prodromal phase of Parkinson’s disease (PD) is characterised by many non-motor symptoms, and these have recently been posited to be predictive of later diagnosis. Genetic rodent models can develop non-motor phenotypes, providing tools to… read more here.
Keywords: motor phenotypes; non motor; parkinson disease; motor ... See more keywords
Cortical Excitability across the ALS Clinical Motor Phenotypes
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DOI: 10.3390/brainsci11060715
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by its marked clinical heterogeneity. Although the coexistence of upper and lower motor neuron signs is a common clinical feature for most patients, there is a wide range of… read more here.
Keywords: across als; motor phenotypes; cortical excitability; motor ... See more keywords
Profiles of Motor-Cognitive Interference in Parkinson’s Disease—The Trail-Walking-Test to Discriminate between Motor Phenotypes
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DOI: 10.3390/brainsci12091217
Abstract: Background and Aims. Most research on Parkinson’s disease (PD) focuses on describing symptoms and movement characteristics. Studies rarely focus on the early detection of PD and the search for suitable markers of a prodromal stage.… read more here.
Keywords: trail walking; motor phenotypes; disease; parkinson disease ... See more keywords