A new Elf5CreERT2‐GFP BAC transgenic mouse model for tracing Elf5 cell lineages in adult tissues
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13390
Abstract: Elf5 is a transcription factor known to regulate critical developmental processes and has been shown to act as a tumour suppressor in multiple cancers. Elf5 knockout mice are embryonically lethal, limiting in vivo studies pertaining… read more here.
Keywords: bac transgenic; elf5creert2 gfp; adult tissues; elf5 ... See more keywords
Oncostatin M expression in the mouse uterus during early pregnancy promotes embryo implantation and decidualization
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13468
Abstract: Oncostatin M (OSM) is a member of the interleukin‐6 (IL‐6) family, which functions in embryo implantation and decidualization. The expression, function and regulation of Osm in mouse uteri during early pregnancy remain unknown. We show… read more here.
Keywords: pregnancy; embryo implantation; expression; decidualization ... See more keywords
Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12276
Abstract: Glutamate carboxypeptidase II (GCPII), also known as prostate‐specific membrane antigen (PSMA) or folate hydrolase, is a metallopeptidase expressed predominantly in the human brain and prostate. GCPII expression is considerably increased in prostate carcinoma, and the… read more here.
Keywords: prostate; gcpii; human gcpii; tissue ... See more keywords
CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13625
Abstract: Cutaneous T-cell lymphoma (CTCL) encompasses two main subtypes: mycosis fungoides and Sezary syndrome. Global response rates for the systemic treatment of mycosis fungoides and Sezary syndrome are approximately 30% and none of these treatments are… read more here.
Keywords: ctcl; ccr4 il2; mouse; model ... See more keywords
Intersection of Immunity, Metabolism, and Muscle Regeneration in an Autoimmune‐Prone MRL Mouse Model
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202306961
Abstract: Due to the limited capacity of mammals to regenerate complex tissues, researchers have worked to understand the mechanisms of tissue regeneration in organisms that maintain that capacity. One example is the MRL/MpJ mouse strain with… read more here.
Keywords: muscle; mrl mpj; mrl; strain ... See more keywords
The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202404326
Abstract: Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents an impending global health challenge. Current management strategies often face setbacks, emphasizing the need for preclinical models that faithfully mimic the human disease and its comorbidities. The liver… read more here.
Keywords: human masld; disease; masld lidpad; model ... See more keywords
Variation in reproduction of the smallest‐bodied primate radiation, the mouse lemurs (Microcebus spp.): A synopsis
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Primatology"
DOI: 10.1002/ajp.22874
Abstract: Reproduction is a fundamental trait in the life history of any species and contributes to species diversity and evolution. Here, we aim to review the barely known variation in reproductive patterns of the smallest‐bodied primate… read more here.
Keywords: primate radiation; variation; reproduction; mouse ... See more keywords
Novel ETV6-RUNX1 Mouse Model to Study the Role of ELF-MF in Childhood B-Acute Lymphoblastic Leukemia: a Pilot Study.
Sign Up to like & getrecommendations! Published in 2019 at "Bioelectromagnetics"
DOI: 10.1002/bem.22193
Abstract: Exposure to extremely low-frequency magnetic fields (ELF-MFs) has been classified by the International Agency for Research on Cancer (IARC) as "possibly carcinogenic to humans," based on limited scientific evidence concerning childhood leukemia. This assessment emphasized… read more here.
Keywords: etv6 runx1; runx1; study; leukemia ... See more keywords
Patterns of cell death in the perinatal mouse forebrain
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24041
Abstract: The importance of cell death in brain development has long been appreciated, but many basic questions remain, such as what initiates or terminates the cell death period. One obstacle has been the lack of quantitative… read more here.
Keywords: death; patterns cell; cell death; forebrain ... See more keywords
A comparative study of the neural stem cell niche in the adult hypothalamus of human, mouse, rat and gray mouse lemur (Microcebus murinus)
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24376
Abstract: The adult brain contains niches of neural stem cells that continuously add new neurons to selected circuits throughout life. Two niches have been extensively studied in various mammalian species including humans, the subventricular zone of… read more here.
Keywords: adult; hypothalamus; cell; neural stem ... See more keywords
Gad1‐promotor‐driven GFP expression in non‐GABAergic neurons of the nucleus endopiriformis in a transgenic mouse line
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24673
Abstract: Transgenic animals have become a widely used model to identify and study specific cell types in whole organs. Promotor‐driven reporter gene labeling of the cells under investigation has promoted experimental efficacy to a large degree.… read more here.
Keywords: non gabaergic; mouse line; transgenic mouse; promotor driven ... See more keywords