Quantification of Lappaconitine in Mouse Blood by UPLC-MS/MS and Its Application to a Pharmacokinetic Study
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DOI: 10.1155/2019/6262105
Abstract: Lappaconitine is extracted from Aconitum sinomontanum Nakai, which belongs to the Ranunculaceae. Lappaconitine is as a diterpenoid alkaloid used as a nonaddictive analgesic. To assure the rational use of the drug, ultrahigh-pressure liquid chromatography tandem… read more here.
Keywords: mouse blood; lappaconitine; application; blood ... See more keywords
Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics
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DOI: 10.1155/2022/3401355
Abstract: An ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of senegenin and tenuifolin in mouse blood was developed. The pharmacokinetics of senegenin and tenuifolin in mice after intravenous (5 mg/kg) and oral (60 mg/kg)… read more here.
Keywords: mouse blood; senegenin tenuifolin; tenuifolin;
Longitudinal Effects of Developmental Bisphenol A Exposure on Epigenome-Wide DNA Hydroxymethylation at Imprinted Loci in Mouse Blood
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DOI: 10.1289/ehp3441
Abstract: Background: Epigenetic machinery plays an important role in genomic imprinting, a developmental process that establishes parent-of-origin–specific monoallelic gene expression. Although a number of studies have investigated the role of 5-methylcytosine in imprinting control, the contribution… read more here.
Keywords: mouse blood; exposure; bpa exposure; hmc ... See more keywords
Pharmacokinetic Study of Deltaline in Mouse Blood Based on UPLCMS/ MS
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DOI: 10.2174/1573412914666181011124515
Abstract: Introduction: Deltaline, an aconitine-type alkaloid, was detected in mouse blood using an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method, and the pharmacokinetics of deltaline following intravenous administration in mice was studied. Materials and Methods: The… read more here.
Keywords: deltaline; mouse blood; study deltaline; blood ... See more keywords