A non-conserved amino acid variant regulates differential signalling between human and mouse CD28
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DOI: 10.1038/s41467-018-03385-8
Abstract: CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic inflammatory response syndrome in humans,… read more here.
Keywords: amino acid; human mouse; mouse cd28; cd28 ... See more keywords