A tecpr2 knockout mouse exhibits age-dependent neuroaxonal dystrophy associated with autophagosome accumulation
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DOI: 10.1080/15548627.2020.1852724
Abstract: ABSTRACT Mutations in the coding sequence of human TECPR2 were recently linked to spastic paraplegia type 49 (SPG49), a hereditary neurodegenerative disorder involving intellectual disability, autonomic-sensory neuropathy, chronic respiratory disease and decreased pain sensitivity. Here,… read more here.
Keywords: tecpr2 knockout; mouse exhibits; age dependent; tecpr2 ... See more keywords