Astrocytic GABAB Receptors in Mouse Hippocampus Control Responses to Behavioral Challenges through Astrocytic BDNF
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Bulletin"
DOI: 10.1007/s12264-020-00474-x
Abstract: Major depressive disorder (MDD) is a common mood disorder that affects almost 20% of the global population. In addition, much evidence has implicated altered function of the gamma-aminobutyric acid (GABAergic) system in the pathophysiology of… read more here.
Keywords: hippocampus; astrocytic gabab; mouse hippocampus; receptors mouse ... See more keywords
3D neuronal mitochondrial morphology in axons, dendrites, and somata of the aging mouse hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109509
Abstract: SUMMARY The brain’s ability to process complex information relies on the constant supply of energy through aerobic respiration by mitochondria. Neurons contain three anatomically distinct compartments—the soma, dendrites, and projecting axons—which have different energetic and… read more here.
Keywords: mitochondrial morphology; mouse hippocampus; morphology axons; neuronal mitochondrial ... See more keywords
Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFκB signaling pathway in the mouse hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2020.110109
Abstract: Methamphetamine (METH) is a highly addictive psychostimulant that causes significant health issues due to high prevalence of its illegal use. Chronic use of METH is associated with cognitive impairments in both human and animal studies,… read more here.
Keywords: tlr4 myd88; cognitive impairments; mouse hippocampus; induced cognitive ... See more keywords
The N6‐methyladenosine RNA landscape in the aged mouse hippocampus
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13755
Abstract: The aged brain is associated with an inevitable decline in cognitive function and increased vulnerability to neurodegenerative disorders. Multiple molecular hallmarks have been associated with the aging nervous system through transcriptomics and proteomic studies. Recently,… read more here.
Keywords: rna; mouse hippocampus; aged mouse; hippocampus ... See more keywords
Age‐Associated Transcriptomic and Epigenetic Alterations in Mouse Hippocampus
Sign Up to like & getrecommendations! Published in 2025 at "Aging Cell"
DOI: 10.1111/acel.70233
Abstract: Aging represents a major risk for human neurodegenerative disorders, such as dementia and Alzheimer's disease, and is associated with a functional decline in neurons and impaired synaptic plasticity, leading to a gradual decline in memory.… read more here.
Keywords: decline; level; mouse hippocampus; cell ... See more keywords
A post-transcriptional regulatory landscape of aging in the female mouse hippocampus
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1119873
Abstract: Aging is associated with substantial physiological changes and constitutes a major risk factor for neurological disorders including dementia. Alterations in gene expression upon aging have been extensively studied; however, an in-depth characterization of post-transcriptional regulatory… read more here.
Keywords: mouse hippocampus; post transcriptional; transcriptional regulatory; age ... See more keywords
The Acute Effects of Amyloid-Beta1–42 on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.01427
Abstract: Alzheimer’s disease (AD) is the leading type of dementia worldwide. Despite an increasing burden of disease due to a rapidly aging population, there is still a lack of complete understanding of the precise pathological mechanisms… read more here.
Keywords: acute effects; mouse hippocampus; str; expression ... See more keywords
Temporal changes in mouse hippocampus transcriptome after pilocarpine-induced seizures
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2024.1384805
Abstract: Introduction Status epilepticus (SE) is a seizure lasting more than 5 min that can have lethal consequences or lead to various neurological disorders, including epilepsy. Using a pilocarpine-induced SE model in mice we investigated temporal… read more here.
Keywords: temporal changes; pilocarpine induced; response; changes mouse ... See more keywords
Aging differentially alters the transcriptome and landscape of chromatin accessibility in the male and female mouse hippocampus
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2024.1334862
Abstract: Aging-related memory impairment and pathological memory disorders such as Alzheimer’s disease differ between males and females, and yet little is known about how aging-related changes in the transcriptome and chromatin environment differ between sexes in… read more here.
Keywords: expression; chromatin accessibility; mouse hippocampus; accessibility ... See more keywords
Regulation and Role of Neuron-Derived Hemoglobin in the Mouse Hippocampus
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105360
Abstract: Hemoglobin (Hb) is the oxygen transport protein in erythrocytes. In blood, Hb is a tetramer consisting of two Hb-alpha (Hb-α) chains and two Hb-beta (Hb-β) chains. A number of studies have also shown that Hb-α… read more here.
Keywords: role; mouse hippocampus; hypoxia; hippocampus ... See more keywords
Methionine Sulfoxide Speciation in Mouse Hippocampus Revealed by Global Proteomics Exhibits Age- and Alzheimer’s Disease-Dependent Changes Targeted to Mitochondrial and Glycolytic Pathways
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25126516
Abstract: Methionine oxidation to the sulfoxide form (MSox) is a poorly understood post-translational modification of proteins associated with non-specific chemical oxidation from reactive oxygen species (ROS), whose chemistries are linked to various disease pathologies, including neurodegeneration.… read more here.
Keywords: age; disease; mitochondrial glycolytic; speciation mouse ... See more keywords