Chimeric Mouse With Humanized Liver Is an Appropriate Animal Model to Investigate Mode of Action for Porphyria-Mediated Hepatocytotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Toxicologic Pathology"
DOI: 10.1177/01926233211027474
Abstract: Porphyrinogenic compounds are known to induce porphyria-mediated hepatocellular injury and subsequent regenerative proliferation in rodents, ultimately leading to hepatocellular tumor induction. However, an appropriate in vivo experimental model to evaluate an effect of porphyrinogenic compounds… read more here.
Keywords: porphyria mediated; mouse humanized; chimeric mouse; model ... See more keywords