DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0285208
Abstract: The decreased β-cell mass and impaired β-cell functionality are the primary causes of diabetes mellitus (DM). Nevertheless, the underlying molecular mechanisms by which β-cell growth and function are controlled are not fully understood. In this… read more here.
Keywords: cell; isolated mouse; mouse islets; dyrk1a inhibitors ... See more keywords
2151-P: Quantification of Tissue Structure in Human and Mouse Islets
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-2151-p
Abstract: The pancreatic islet is a complex tissue consisting of multiple endocrine cell types, capillaries, and a peri-islet basement membrane. The 3D organization of cells, blood vessels, and basement membrane (BM), enhances islet function by (1)… read more here.
Keywords: mouse islets; structure; cell; quantification ... See more keywords
2132-P: Single-Cell RNA-Sequencing of Mouse Islets after Inflammatory Cytokine Exposure
Sign Up to like & getrecommendations! Published in 2020 at "Diabetes"
DOI: 10.2337/db20-2132-p
Abstract: Type 1 diabetes is an autoimmune disease caused by destruction of pancreatic β-cells. During disease progression, β-cells are exposed to proinflammatory cytokines like interleukin-1β (IL-1β) and interferon-γ (IFN-γ), stimulating them to express inducible nitric oxide… read more here.
Keywords: single cell; mouse islets; cell rna; expression ... See more keywords