Proteomics coupled transcriptomics reveals lipopolysaccharide inhibiting peroxisome proliferator-activated receptors signalling pathway to reduce lipid droplets accumulation in mouse liver.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202300043
Abstract: Lipid droplets (LDs) are multifunctional organelles consisting of a central compartment of non-polar lipids shielded from the cytoplasm by a phospholipid monolayer. The excessive accumulation of LDs in cells is closely related to the development… read more here.
Keywords: peroxisome proliferator; proliferator activated; lipid droplets; mouse liver ... See more keywords
Kupffer Cell and Monocyte-Derived Macrophage Identification by Immunofluorescence on Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse Liver Sections.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0704-6_6
Abstract: Kupffer cells are the liver-resident macrophages and represent the first line of defense between the pathogens circulating from the intestines through the portal vein and systemic circulation. Recent works have highlighted the complex heterogeneity of… read more here.
Keywords: fixed paraffin; paraffin embedded; formalin fixed; macrophage ... See more keywords
Immunohistochemistry (IHC): Chromogenic Detection of 3-Phosphohistidine Proteins in Formaldehyde-Fixed, Frozen Mouse Liver Tissue Sections.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9884-5_13
Abstract: The development of antibodies that specifically detect histidine-phosphorylated proteins is a recent achievement and allows potential roles of histidine phosphorylated proteins in pathological and physiological conditions to be characterized. Immunohistochemical analyses enable the detection of… read more here.
Keywords: detection; tissue; phosphohistidine proteins; detection phosphohistidine ... See more keywords
Genomic comparisons between hepatocarcinogenic and non-hepatocarcinogenic organophosphate insecticides in the mouse liver.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.153046
Abstract: Short-term biomarkers of toxicity have an increasingly important role in the screening and prioritization of new chemicals. In this study, we examined early indicators of liver toxicity for three reference organophosphate (OP) chemicals, which are… read more here.
Keywords: comparisons hepatocarcinogenic; liver cancer; parathion; hepatocarcinogenic non ... See more keywords
Functional Analysis of Human Hepatocytes Isolated From Chimeric Mouse Liver.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.06.035
Abstract: Chimeric mice with humanized liver were first established by transplanting primary human hepatocytes (PHHs) isolated from a Japanese 27-year-old donor into complementary DNA-urokinase-type plasminogen activator/severe combined immunodeficiency mice. The PHHs from the Japanese donor increased… read more here.
Keywords: analysis human; chimeric mouse; human hepatocytes; mouse liver ... See more keywords
Circadian clock-dependent and -independent posttranscriptional regulation underlies temporal mRNA accumulation in mouse liver
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1715225115
Abstract: Significance Rhythms in gene expression propelled by the circadian clock and environmental signals are ubiquitous across cells and tissues. In particular, in mouse tissues, thousands of transcripts show oscillations with a period of 24 hours.… read more here.
Keywords: posttranscriptional regulation; regulation; circadian clock; mouse liver ... See more keywords
The experimental study of mouse liver in magneto-acousto-electrical tomography by scan mode.
Sign Up to like & getrecommendations! Published in 2020 at "Physics in medicine and biology"
DOI: 10.1088/1361-6560/abb4bb
Abstract: Magneto-acousto-electrical tomography (MAET) is an imaging method coupled with sound field and magnetic field. The aim of this study is to present some novel experimental results of the mouse liver for the magneto-acousto-electrical tomography measured… read more here.
Keywords: magneto acousto; electrical tomography; mouse liver; acousto electrical ... See more keywords
Evaluation on the Metabolic Activity of Two Carboxylesterase Isozymes in Mouse Liver Microsomes by a LC-MS/MS Method.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmac105
Abstract: An applicable method for the precise measurement of major carboxylesterase (CESs) activity in liver still limited. Clopidogrel and irinotecan are specific substrates for CES1 and CES2, respectively. Clopidogrel is metabolized to the inactive metabolite clopidogrel… read more here.
Keywords: evaluation metabolic; mouse liver; liver microsomes; metabolic activity ... See more keywords
A versatile transposon-based technology to generate loss- and gain-of-function phenotypes in the mouse liver
Sign Up to like & getrecommendations! Published in 2022 at "BMC Biology"
DOI: 10.1186/s12915-022-01262-x
Abstract: Background Understanding the contribution of gene function in distinct organ systems to the pathogenesis of human diseases in biomedical research requires modifying gene expression through the generation of gain- and loss-of-function phenotypes in model organisms,… read more here.
Keywords: expression; mouse liver; function phenotypes; technology ... See more keywords
Visualization of quantitative lipid distribution in mouse liver through near-infrared hyperspectral imaging.
Sign Up to like & getrecommendations! Published in 2021 at "Biomedical optics express"
DOI: 10.1364/boe.413712
Abstract: Lipid distribution in the liver provides crucial information for diagnosing the severity of fatty liver and fatty liver-associated liver cancer. Therefore, a noninvasive, label-free, and quantitative modality is eagerly anticipated. We report near-infrared hyperspectral imaging… read more here.
Keywords: near infrared; liver; infrared hyperspectral; lipid distribution ... See more keywords
Nonstructural 5A Protein of Hepatitis C Virus Interferes with Toll-Like Receptor Signaling and Suppresses the Interferon Response in Mouse Liver
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0170461
Abstract: The hepatitis C virus nonstructural protein NS5A is involved in resistance to the host immune response, as well as the viral lifecycle such as replication and maturation. Here, we established transgenic mice expressing NS5A protein… read more here.
Keywords: protein; response; hepatitis virus; receptor ... See more keywords