Isolation and Purification of Epithelial and Endothelial Cells from Mouse Lung.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7896-0_6
Abstract: It is well established that responses to inhaled environmental agents are controlled by the coordinated actions by multiple immune cell types, including macrophages, dendritic cells, and lymphocytes. Recent evidence indicates that some structural cells can… read more here.
Keywords: mouse lung; cells mouse; epithelial endothelial; isolation purification ... See more keywords
Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.01.009
Abstract: The lung microvasculature is essential for gas exchange and commonly considered homogeneous. We show that VEGFA from the epithelium is required for a distinct endothelial cell (EC) population in the mouse lung. Vegfa is predominantly… read more here.
Keywords: car4 ecs; mouse lung; distinct endothelial; population mouse ... See more keywords
Effective silencing of ENaC by siRNA delivered with epithelial-targeted nanocomplexes in human cystic fibrosis cells and in mouse lung
Sign Up to like & getrecommendations! Published in 2018 at "Thorax"
DOI: 10.1136/thoraxjnl-2017-210670
Abstract: Introduction Loss of the cystic fibrosis transmembrane conductance regulator in cystic fibrosis (CF) leads to hyperabsorption of sodium and fluid from the airway due to upregulation of the epithelial sodium channel (ENaC). Thickened mucus and… read more here.
Keywords: cystic fibrosis; mouse lung; enac; effective silencing ... See more keywords
Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010343
Abstract: The continuous emergence of severe acute respiratory coronavirus 2 (SARS-CoV-2) variants and the increasing number of breakthrough infection cases among vaccinated people support the urgent need for research and development of antiviral drugs. Viral entry… read more here.
Keywords: mouse lung; sars cov; drug; infection ... See more keywords
Associating local strains to global pressure–volume mouse lung mechanics using digital image correlation
Sign Up to like & getrecommendations! Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15466
Abstract: Pulmonary diseases alter lung mechanical properties, can cause loss of function, and necessitate use of mechanical ventilation, which can be detrimental. Investigations of lung tissue (local) scale mechanical properties are sparse compared to that of… read more here.
Keywords: lung mechanics; mouse lung; volume; pressure ... See more keywords
Mapping of the Sensory Innervation of the Mouse Lung by Specific Vagal and Dorsal Root Ganglion Neuronal Subsets
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0026-22.2022
Abstract: Abstract The airways are densely innervated by sensory afferent nerves, whose activation regulates respiration and triggers defensive reflexes (e.g., cough, bronchospasm). Airway innervation is heterogeneous, and distinct afferent subsets have distinct functional responses. However, little… read more here.
Keywords: innervation; vagal dorsal; innervation mouse; mouse lung ... See more keywords
Periodontopathic Bacterium Fusobacterium nucleatum Affects Matrix Metalloproteinase-9 Expression in Human Alveolar Epithelial Cells and Mouse Lung
Sign Up to like & getrecommendations! Published in 2022 at "In Vivo"
DOI: 10.21873/invivo.12749
Abstract: Background/Aim: Despite evidence of an association between pulmonary diseases and periodontopathic bacteria, the molecular mechanisms remain unknown. Matrix metalloproteinase-9 (MMP9) plays important roles in pneumonia, chronic obstructive pulmonary disease, and asthma; therefore, we assessed the… read more here.
Keywords: mouse lung; expression; mmp9; fusobacterium nucleatum ... See more keywords
Spatial Transcriptome Uncovers the Mouse Lung Architectures and Functions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.858808
Abstract: Diseases leading to lung structural and functional disruption pose a major threat to human health (Tobin, 2005; Nathan et al., 2019; Podolanczuk et al., 2021). Mouse models represent a common choice to investigate physiological and… read more here.
Keywords: scrna seq; transcriptome uncovers; mouse lung; lung ... See more keywords