Characterization of the spectrum of trivalent VAV1‐mutation‐driven tumours using a gene‐edited mouse model
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13295
Abstract: Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall‐cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene‐edited mouse model that… read more here.
Keywords: vav1; edited mouse; gene edited; gene ... See more keywords
LKB1 suppresses androgen synthesis in a mouse model of hyperandrogenism via IGF‐1 signaling
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12723
Abstract: Polycystic ovary syndrome (PCOS) is a major cause of anovulatory sterility in women, and most PCOS patients exhibit hyperandrogenism (HA). Liver kinase b1 (LKB1) is a tumor suppressor that has recently been reported to be… read more here.
Keywords: via igf; igf signaling; androgen synthesis; hyperandrogenism ... See more keywords
Tissue xanthine oxidoreductase activity in a mouse model of aristolochic acid nephropathy
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13083
Abstract: Xanthine oxidoreductase (XOR) is a critical enzyme in purine metabolism and uric acid production, and its levels are reported to increase during stress, thereby promoting organ damage. Herein, we investigated the activity of XOR in… read more here.
Keywords: activity; tissue; model aristolochic; xor ... See more keywords
Effects of antiepileptic drugs in a new TSC/mTOR‐dependent epilepsy mouse model
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.50829
Abstract: An epilepsy mouse model for Tuberous Sclerosis Complex (TSC) was developed and validated to investigate the mechanisms underlying epileptogenesis. Furthermore, the possible antiepileptogenic properties of commonly used antiepileptic drugs (AEDs) and new compounds were assessed. read more here.
Keywords: antiepileptic drugs; mouse model; epilepsy mouse;
Protective Effects of Lovastatin in a Population‐Based ALS Study and Mouse Model
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Neurology"
DOI: 10.1002/ana.26600
Abstract: The objective of this study was to use a novel combined pharmacoepidemiologic and amyotrophic lateral sclerosis (ALS) mouse model approach to identify potential motor neuron protective medications. read more here.
Keywords: protective effects; effects lovastatin; based als; population based ... See more keywords
Untargeted metabolomics reveals hepatic metabolic disorder in the BTBR mouse model of autism and the significant role of liver in autism.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biochemistry and function"
DOI: 10.1002/cbf.3811
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder, and the etiology is unknown. Metabolic dysfunction is present in patients with ASD. In the current study, untargeted metabolomics was employed to screen the differential metabolites in… read more here.
Keywords: untargeted metabolomics; mouse model; liver; autism ... See more keywords
The Mouse Model of Infection with Citrobacter rodentium
Sign Up to like & getrecommendations! Published in 2017 at "Current Protocols in Immunology"
DOI: 10.1002/cpim.34
Abstract: Citrobacter rodentium is a murine mucosal pathogen used as a model to elucidate the molecular and cellular pathogenesis of infection with two clinically important human gastrointestinal pathogens, enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli… read more here.
Keywords: rodentium; infection; mouse model; citrobacter rodentium ... See more keywords
The involvement of protein TNFSF18 in promoting p‐STAT1 phosphorylation to induce coronary microcirculation disturbance in atherosclerotic mouse model
Sign Up to like & getrecommendations! Published in 2020 at "Drug Development Research"
DOI: 10.1002/ddr.21735
Abstract: The inflammation of coronary endothelium was critically involved in the pathogenesis of atherosclerosis. The purpose of the study was to reveal the roles of TNFSF18 in promoting p‐STAT1 phosphorylation to induce disturbance of coronary microcirculation… read more here.
Keywords: tnfsf18; model; mouse model; stat1 phosphorylation ... See more keywords
Generation of a hypoxia‐sensing mouse model
Sign Up to like & getrecommendations! Published in 2019 at "genesis"
DOI: 10.1002/dvg.23352
Abstract: Oxygen (O2) homeostasis is essential to the metazoan life. O2‐sensing or hypoxia‐regulated molecular pathways are intimately involved in a wide range of critical cellular functions and cell survival from embryogenesis to adulthood. In this report,… read more here.
Keywords: hypoxia sensing; hypoxia; sensing mouse; mouse model ... See more keywords
Generation of Pecam1 endothelial specific dual reporter mouse model.
Sign Up to like & getrecommendations! Published in 2020 at "Genesis"
DOI: 10.1002/dvg.23384
Abstract: Endothelial cells are specialized epithelium lining the interior surface of vessels and play fundamental roles in angiogenesis, vascular permeability, and immune response. To identify endothelial cells in vivo, we constructed a Pecam1nlacZ-H2B-GFP/+ knock-in mouse model… read more here.
Keywords: reporter mouse; gfp; endothelial cells; mouse model ... See more keywords
A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201746934
Abstract: The TNF family cytokines B‐cell activating factor (BAFF) and a proliferation‐inducing ligand (APRIL) support plasma cell survival. It is known that inhibitors of BAFF only (BAFFR‐Fc) or BAFF and APRIL (TACI‐Fc) administered early enough in… read more here.
Keywords: plasma; taci; plasma cells; baff ... See more keywords