Hypothesis‐driven investigations of diverse pharmacological targets in two mouse models of autism
Sign Up to like & getrecommendations! Published in 2019 at "Autism Research"
DOI: 10.1002/aur.2066
Abstract: Autism spectrum disorder is a neurodevelopmental syndrome diagnosed primarily by persistent deficits in social interactions and communication, unusual sensory reactivity, motor stereotypies, repetitive behaviors, and restricted interests. No FDA‐approved medical treatments exist for the diagnostic… read more here.
Keywords: models autism; mouse models; autism; pharmacological targets ... See more keywords
Dendritic cell functions in vivo: A user's guide to current and next‐ generation mutant mouse models
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149513
Abstract: DCs do not just excel in antigen presentation. They orchestrate information transfer from innate to adaptive immunity by sensing and integrating a variety of danger signals, and translating them to naïve T cells, to mount… read more here.
Keywords: mouse; next generation; generation mutant; mouse models ... See more keywords
Lipocalin 2 attenuates oligodendrocyte loss and immune cell infiltration in mouse models for multiple sclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24245
Abstract: Multiple sclerosis (MS) is a central nervous system disease characterized by both degenerative and inflammatory processes. Various mediators are involved in the interplay of degeneration and innate immunity on one hand and peripheral adaptive immunity… read more here.
Keywords: cell; loss; mouse; model ... See more keywords
Embracing microbial exposure in mouse research
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ri0718-273r
Abstract: Research using mouse models have contributed essential knowledge toward our current understanding of how the human immune system functions. One key difference between humans and typical laboratory mice, however, is exposure to pathogens in their… read more here.
Keywords: research; mouse; immune system; mouse models ... See more keywords
Visual discrimination and inhibitory control deficits in mouse models of Down syndrome: A pilot study using rodent touchscreen technology
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25160
Abstract: Several non‐verbal cognitive and behavioral tests have been developed to assess learning deficits in humans with Down syndrome (DS). Here we used rodent touchscreen paradigms in adult male mice to investigate visual discrimination (VD) learning… read more here.
Keywords: rodent touchscreen; visual discrimination; inhibitory control; learning deficits ... See more keywords
Magnetic resonance imaging approaches for studying mouse models of multiple sclerosis: A mini review.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neuroscience research"
DOI: 10.1002/jnr.25193
Abstract: Given that multiple sclerosis (MS) is a complex disease with an unclear etiology, a single animal model is unlikely to accurately represent all aspects of pathology and clinical features of the human condition. However, the… read more here.
Keywords: magnetic resonance; multiple sclerosis; mouse models; resonance imaging ... See more keywords
Assessment of iron nanoparticle distribution in mouse models using ultrashort‐echo‐time MRI
Sign Up to like & getrecommendations! Published in 2022 at "Nmr in Biomedicine"
DOI: 10.1002/nbm.4690
Abstract: Microscopic magnetic field inhomogeneities caused by iron deposition or tissue‐air interfaces may result in rapid decay of transverse magnetization in MRI. The aim of this study is to detect and quantify the distribution of iron‐based… read more here.
Keywords: time; nanoparticle distribution; iron; distribution ... See more keywords
Proteomic profiling of the hypothalamus in two mouse models of narcolepsy
Sign Up to like & getrecommendations! Published in 2017 at "PROTEOMICS"
DOI: 10.1002/pmic.201600478
Abstract: Narcolepsy is a disabling neurological disorder of sleepiness linked to the loss of neurons producing orexin neuropeptides in the hypothalamus. Two well‐characterized phenotypic mouse models of narcolepsy, loss‐of‐function (orexin‐knockout), and progressive loss of orexin (orexin/ataxin‐3)… read more here.
Keywords: models narcolepsy; orexin; mouse models; hypothalamus two ... See more keywords
Daikenchuto (TU‐100) Suppresses Tumor Development in the Azoxymethane and APCmin/+ Mouse Models of Experimental Colon Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Phytotherapy Research"
DOI: 10.1002/ptr.5735
Abstract: Chemopreventative properties of traditional medicines and underlying mechanisms of action are incompletely investigated. This study demonstrates that dietary daikenchuto (TU‐100), comprised of ginger, ginseng, and Japanese pepper effectively suppresses intestinal tumor development and progression in… read more here.
Keywords: mouse models; apcmin mouse; tumor development; daikenchuto 100 ... See more keywords
Experimental Mouse Models of Asthma and Analysis of CD4 T Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1311-5_25
Abstract: Asthma is a highly prevalent lung disease, characterized by airway dysfunction and chronic inflammation. Asthma occurs in both children and adults, but frequently originates in early life. Heterogeneous asthma phenotypes exist, but Th2 cells are… read more here.
Keywords: mouse models; experimental mouse; asthma analysis; analysis cd4 ... See more keywords
Engraftment of Human Hematopoietic Cells in Biomaterials Implanted in Immunodeficient Mouse Models.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1425-9_18
Abstract: Over the last 20 years, significant progress has been made in the development of immunodeficient mouse models that now represents the gold standard tool in stem cell biology research. The latest major improvement has been the… read more here.
Keywords: mouse models; immunodeficient mouse; engraftment human; human hematopoietic ... See more keywords