Comprehensive lipidomics of mouse plasma using class-specific surrogate calibrants and SWATH acquisition for large-scale lipid quantification in untargeted analysis.
Sign Up to like & getrecommendations! Published in 2019 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2019.08.030
Abstract: Lipidomics has gained rising attention in recent years. Several strategies for lipidomic profiling have been developed, with targeted analysis of selected lipid species, typically utilized for lipid quantification by low-resolution triple quadrupole MS/MS, and untargeted… read more here.
Keywords: untargeted analysis; acquisition; surrogate calibrants; quantification ... See more keywords
A simple and sensitive liquid chromatography–tandem mass spectrometry method for trans‐&egr;‐viniferin quantification in mouse plasma and its application to a pharmacokinetic study in mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2016.11.044
Abstract: HIGHLIGHTSFirst LC–MS/MS method for trans‐&egr;‐viniferin quantification in mouse plasma.A simple protein precipitation that allowed for efficient/reproducible recovery yields was used.The small plasma volume (10 &mgr;l) supports the ability to examine pharmacokinetics in mice. ABSTRACT In… read more here.
Keywords: method; egr viniferin; quantification; trans egr ... See more keywords
Development and validation of an LC–MS/MS method for quantitative determination of GS87, a novel antineoplastic agent, in mouse plasma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.02.034
Abstract: HighlightsA simple, selective and sensitive LC–MS/MS method was developed for the quantitative measurement of GS87, a GSK3 inhibitor, in mouse plasma.It uses liquid‐liquid extraction for sample preparation.The method was validated in accordance with the US‐FDA… read more here.
Keywords: gs87; validation method; mouse plasma; method ... See more keywords
Simultaneous determination of a promising anti-brain tumor agent CAT3 and its two major metabolites in mouse plasma and brain by a LC-MS/MS method.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2020.113106
Abstract: A rapid and reproducible method with high selectivity was developed for simultaneous determination of a promising anti-brain tumor agent CAT3 and its two metabolites PF403 and GLU-PF403 in mouse plasma and brain. An economic deproteinization… read more here.
Keywords: simultaneous determination; plasma brain; method; pf403 ... See more keywords
Quantitative evaluation and pharmacokinetic characteristics of the irreversible BTK inhibitor zanubrutinib in mouse plasma using LC-MS/MS
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Mass Spectrometry"
DOI: 10.1177/14690667221128934
Abstract: Zanubrutinib (BGB-3111) belongs to the class of irreversible inhibitors of Bruton's tyrosine kinase (BTK) for treating B-cell malignancies. A validated assay with excellent sensitivity, selectivity, and simplicity is required to measure plasma concentration and investigate… read more here.
Keywords: zanubrutinib; mouse plasma; zanubrutinib mouse; quantitative evaluation ... See more keywords
Determination and pharmacokinetics study of UK-5099 in mouse plasma by LC–MS/MS
Sign Up to like & getrecommendations! Published in 2022 at "BMC Veterinary Research"
DOI: 10.1186/s12917-022-03245-0
Abstract: Background UK-5099 is a potent mitochondrial acetone carrier inhibitor, that exhibits anticancer activity. Recently, the anti- Toxoplasma gondii activity of UK-5099 was proposed, and in vivo studies of its pharmacokinetics in BALB/c mice are necessary… read more here.
Keywords: determination pharmacokinetics; 5099 mouse; mouse plasma;