A Susceptibility Locus on Chromosome 13 Profoundly Impacts the Stability of Genomic Imprinting in Mouse Pluripotent Stem Cells.
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DOI: 10.1016/j.celrep.2020.02.073
Abstract: Cultured pluripotent cells accumulate detrimental chromatin alterations, including DNA methylation changes at imprinted genes known as loss of imprinting (LOI). Although the occurrence of LOI is considered a stochastic phenomenon, here we document a genetic… read more here.
Keywords: susceptibility locus; mouse pluripotent; pluripotent cells; chromosome ... See more keywords