Neuronal cell-subtype specificity of neural synchronization in mouse primary visual cortex
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10498-1
Abstract: Spatiotemporally synchronised neuronal activity is central to sensation, motion and cognition. Brain circuits consist of dynamically interconnected neuronal cell-types, thus elucidating how neuron types synergise within the network is key to understand the neuronal orchestra.… read more here.
Keywords: network; mouse primary; neuronal cell; primary visual ... See more keywords
Novel stimuli evoke excess activity in the mouse primary visual cortex
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2108882119
Abstract: Significance Rapid detection and processing of stimulus novelty are key elements of adaptive behavior. Predictive coding theories postulate that novel stimuli should be encoded differently from familiar stimuli. Here, we show that the majority of… read more here.
Keywords: primary visual; visual cortex; mouse primary; activity ... See more keywords
Zika virus-induced hyper excitation precedes death of mouse primary neuron
Sign Up to like & getrecommendations! Published in 2018 at "Virology Journal"
DOI: 10.1186/s12985-018-0989-4
Abstract: BackgroundZika virus infection in new born is linked to congenital syndromes, especially microcephaly. Studies have shown that these neuropathies are the result of significant death of neuronal progenitor cells in the central nervous system of… read more here.
Keywords: death; mouse primary; zika virus; virus infection ... See more keywords
Muscarinic Modulation of SK2-Type K+ Channels Promotes Intrinsic Plasticity in L2/3 Pyramidal Neurons of the Mouse Primary Somatosensory Cortex
Sign Up to like & getrecommendations! Published in 2020 at "eNeuro"
DOI: 10.1523/eneuro.0453-19.2020
Abstract: Abstract Muscarinic acetylcholine receptors (mAChRs) inhibit small-conductance calcium-activated K+ channels (SK channels) and enhance synaptic weight via this mechanism. SK channels are also involved in activity-dependent plasticity of membrane excitability (“intrinsic plasticity”). Here, we investigate… read more here.
Keywords: mouse primary; plasticity; sk2; intrinsic plasticity ... See more keywords
Poricoic acid a inhibits mitochondrial dysfunction in myocardial infarction by activating SIRT3
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Biochemistry and Nutrition"
DOI: 10.3164/jcbn.24-208
Abstract: Acute myocardial infarction (MI) is the most severe clinical manifestation of ischemic heart disease. Despite this, the mechanisms that disrupt mitochondrial homeostasis and contribute to cardiomyocyte loss during MI are poorly understood, emphasizing the urgent… read more here.
Keywords: poricoic acid; mitochondrial dysfunction; myocardial infarction; activating sirt3 ... See more keywords
Mapping the Plasticity of Morphology, Molecular Properties and Function in Mouse Primary Microglia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.811061
Abstract: Microglia exert diverse functions by responding in diverse ways to different stimuli, yet little is known about the plasticity of various phenotypes that microglia display. We used interferon (IFN)-γ, interleukin (IL)-4 and IL-10 to induce… read more here.
Keywords: mouse primary; phenotype; plasticity; primary microglia ... See more keywords
Dendritic synaptome of calcium-binding protein containing GABAergic interneurons in the mouse primary visual cortex
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2025.1644572
Abstract: This article aims to provide a synaptic input database called, dendritic synaptome for dendrites of calcium-binding protein-containing interneurons [calbindin-D28K (CB+), calretinin (CR+), parvalbumin (PV+)] employing a modified correlated light and EM method, the “mirror-technique” that… read more here.
Keywords: presynaptic boutons; protein containing; dendritic synaptome; calcium binding ... See more keywords
GB1a Activates SIRT6 to Regulate Lipid Metabolism in Mouse Primary Hepatocytes
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119540
Abstract: Lipid accumulation, oxidative stress, and inflammation in hepatocytes are features of nonalcoholic fatty liver disease (NAFLD). Garcinia biflavonoid 1a (GB1a) is a natural product capable of hepatic protection. In this study, the effect of GB1a… read more here.
Keywords: mouse primary; gb1a reduced; primary hepatocytes; gb1a ... See more keywords
Transcriptional Consequences of MeCP2 Knockdown and Overexpression in Mouse Primary Cortical Neurons
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26189032
Abstract: Rett syndrome (RTT) and MECP2 duplication syndrome, a subtype of autism spectrum disorder (ASD), are neurodevelopmental disorders caused by MeCP2 loss and gain of function, respectively. While MeCP2 is known to regulate transcription through its… read more here.
Keywords: mecp2 knockdown; consequences mecp2; primary cortical; cortical neurons ... See more keywords