Mode of action and human relevance assessment of male CD‐1 mouse renal adenocarcinoma associated with lifetime exposure to empagliflozin
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4329
Abstract: Inhibition of sodium‐glucose cotransporter‐2 (SGLT2) has been shown to be a safe and efficacious approach to support managing Type 2 diabetes. In the 2‐year carcinogenicity study with the SGLT2 inhibitor empagliflozin in CD‐1 mice, an… read more here.
Keywords: mouse renal; male mouse; mode action; mice ... See more keywords
A refined protocol for the isolation and monoculture of primary mouse renal peritubular endothelial cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2023.1114726
Abstract: During an episode of acute kidney injury (AKI), a sudden and rapid decline in renal function is often accompanied by a persistent reduction in mitochondrial function, microvasculature dysfunction/rarefaction, and tubular epithelial injury/necrosis. Additionally, patients who… read more here.
Keywords: primary renal; peritubular endothelial; isolation; mouse renal ... See more keywords