The SAM domain of mouse SAMHD1 is critical for its activation and regulation
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DOI: 10.1038/s41467-017-02783-8
Abstract: Human SAMHD1 (hSAMHD1) is a retroviral restriction factor that blocks HIV-1 infection by depleting the cellular nucleotides required for viral reverse transcription. SAMHD1 is allosterically activated by nucleotides that induce assembly of the active tetramer.… read more here.
Keywords: mouse samhd1; sam domain; samhd1; domain ... See more keywords