Fate‐mapping analysis of cochlear cells expressing Atoh1 mRNA via a new Atoh13*HA‐P2A‐Cre knockin mouse strain
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.453
Abstract: Atoh1 is recognized to be essential for cochlear hair cell (HC) development. However, Atoh1 temporal and spatial expression patterns remain widely debated. Here, we aimed to obtain evidence to resolve the controversies regarding Atoh1 expression… read more here.
Keywords: mouse strain; atoh13 p2a; knockin mouse; p2a cre ... See more keywords
Organ defects of the Usp7K444R mutant mouse strain indicate the essential role of K63-polyubiquitinated Usp7 in organ formation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical journal"
DOI: 10.1016/j.bj.2022.02.002
Abstract: BACKGROUND K63-linked polyubiquitination of proteins have nonproteolytic functions and regulate the activity of many signal transduction pathways. USP7, a HIF1α deubiquitinase, undergoes K63-linked polyubiquitination under hypoxia. K63-polyubiquitinated USP7 serves as a scaffold to anchor HIF1α,… read more here.
Keywords: organ defects; polyubiquitinated usp7; k63 polyubiquitinated; role ... See more keywords
Assessment of mouse strain differences in baseline esterase activities and toxic response to sarin.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology"
DOI: 10.1016/j.tox.2018.08.016
Abstract: Genetics likely play a role in various responses to nerve agent (NA) exposure, as genetic background plays an important role in behavioral, neurological, and physiological responses. This study uses different mouse strains to identify if… read more here.
Keywords: response; sarin; mouse strain; strain ... See more keywords
A novel mouse strain optimized for chronic human antibody administration
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123002119
Abstract: Significance Species differences in IgG Fc–Fcγ receptor (FcγR) interactions have made humanized mouse models an attractive strategy to evaluate the efficacy and toxicity of human antibodies. We previously published a humanized FcγR mouse model that… read more here.
Keywords: human igg; administration; mouse strain; mouse ... See more keywords
Mouse strain-specific acute respiratory effects of nicotine unrelated to nicotine metabolism
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology Mechanisms and Methods"
DOI: 10.1080/15376516.2019.1628141
Abstract: Abstract Plethysmograph measurement of respiratory phenotypes provides a highly sensitive means to study nicotine response in experimental model animals. We measured average respiratory frequency, tidal volume, minute volume and inspiratory time in C3H/HeJ and C57BL/6J… read more here.
Keywords: acute respiratory; mouse strain; strain specific; specific acute ... See more keywords
Research Letter: Is the 129S1/SvImJ Mouse Strain More Suitable to Study Anticoagulant-Related Nephropathy Than the C57BL/6 Strain?
Sign Up to like & getrecommendations! Published in 2023 at "Canadian Journal of Kidney Health and Disease"
DOI: 10.1177/20543581231160507
Abstract: Background: We have previously demonstrated that excessive anticoagulation with warfarin or dabigatran may result in acute kidney injury with red blood cell (RBC) tubular casts in some patients with chronic kidney disease, and this condition… read more here.
Keywords: day; mouse strain; c57bl; strain ... See more keywords