miRNA‐regulated transcription associated with mouse strains predisposed to hypnotic effects of ethanol
Sign Up to like & getrecommendations! Published in 2018 at "Brain and Behavior"
DOI: 10.1002/brb3.989
Abstract: Studying innate sensitivity to ethanol can be an important first step toward understanding alcohol use disorders. In brain, we investigated transcripts, with evidence of miRNA modulation related to a predisposition to the hypnotic effect of… read more here.
Keywords: strains predisposed; regulated transcription; mouse strains; mirna regulated ... See more keywords
The Genetic Basis of Reporter Mouse Strains.
Sign Up to like & getrecommendations! Published in 2021 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-33-6064-8_21
Abstract: Genetically engineered mouse (GEM) models have been revolutionizing the biomedical studies on deciphering the physiological roles of genes in vivo. In addition to deactivating a gene in mice, diverse strategies have been created to monitor… read more here.
Keywords: reporter mouse; genetic basis; mouse strains; basis reporter ... See more keywords
Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity
Sign Up to like & getrecommendations! Published in 2020 at "Behavior Genetics"
DOI: 10.1007/s10519-020-10014-y
Abstract: We conducted whole-genome sequencing of four inbred mouse strains initially selected for high (H1, H2) or low (L1, L2) open-field activity (OFA), and then examined strain distribution patterns for all DNA variants that differed between… read more here.
Keywords: whole genome; high low; mouse strains; inbred mouse ... See more keywords
Dopamine synthesis in alcohol drinking-prone and -resistant mouse strains.
Sign Up to like & getrecommendations! Published in 2017 at "Alcohol"
DOI: 10.1016/j.alcohol.2016.05.005
Abstract: Alcoholism is a prevalent and debilitating neuropsychiatric disease, and much effort has been aimed at elucidating the neurobiological mechanisms underlying maladaptive alcohol drinking in an effort to design rational treatment strategies. In preclinical literature, the… read more here.
Keywords: mouse strains; alcohol; dopamine synthesis; dopamine ... See more keywords
Initial genetic dissection of serum neuroactive steroids following chronic intermittent ethanol across BXD mouse strains.
Sign Up to like & getrecommendations! Published in 2017 at "Alcohol"
DOI: 10.1016/j.alcohol.2016.07.011
Abstract: Neuroactive steroids modulate alcohol's impact on brain function and behavior. Ethanol exposure alters neuroactive steroid levels in rats, humans, and some mouse strains. We conducted an exploratory analysis of the neuroactive steroids (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP), (3α,5α)-3,21-dihydroxypregnan-20-one… read more here.
Keywords: neuroactive steroids; variation; thp; mouse strains ... See more keywords
Variable behavior and repeated learning in two mouse strains: Developmental and genetic contributions
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Processes"
DOI: 10.1016/j.beproc.2018.06.007
Abstract: Behavioral inflexibility is often assessed using reversal learning tasks, which require a relatively low degree of response variability. No studies have assessed sensitivity to reinforcement contingencies that specifically select highly variable response patterns in mice,… read more here.
Keywords: variability; mouse strains; reinforcement; mice ... See more keywords
Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.01.009
Abstract: Objective In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In this study, we aimed to identify key genes involved in pancreatic beta cell… read more here.
Keywords: insulin; insulin secretion; mouse strains; multiple mouse ... See more keywords
Easy and quick (EQ) sperm freezing method for urgent preservation of mouse strains
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93604-y
Abstract: Cryopreservation of mouse spermatozoa is widely used for the efficient preservation and safe transport of valuable mouse strains. However, the current cryopreservation method requires special containers (plastic straws), undefined chemicals (e.g., skim milk), liquid nitrogen,… read more here.
Keywords: sperm freezing; quick sperm; mouse strains; easy quick ... See more keywords
Extensive variation in the intelectin gene family in laboratory and wild mouse strains
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-94679-3
Abstract: Intelectins are a family of multimeric secreted proteins that bind microbe-specific glycans. Both genetic and functional studies have suggested that intelectins have an important role in innate immunity and are involved in the etiology of… read more here.
Keywords: intelectin; intelectin genes; mouse strains; laboratory ... See more keywords
Use of anti-inhibin monoclonal antibody for increasing the litter size of mouse strains and its application to in vivo-genome editing technology
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac068
Abstract: Abstract The litter size of mouse strains is determined by the number of oocytes naturally ovulated. Many attempts have been made to increase litter sizes by conventional superovulation regimens (e.g., using equine or human gonadotropins,… read more here.
Keywords: genome editing; anti inhibin; litter size; mouse strains ... See more keywords
Modeling diseases in multiple mouse strains for precision medicine studies.
Sign Up to like & getrecommendations! Published in 2017 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00123.2016
Abstract: The genetic basis of the phenotypic variability observed in patients can be studied in mice by generating disease models through genetic or chemical interventions in many genetic backgrounds where the clinical phenotypes can be assessed… read more here.
Keywords: medicine; diseases multiple; mouse strains; modeling diseases ... See more keywords