Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000279
Abstract: BACKGROUND AND AIMS NAFLD has become a major metabolic disease worldwide. A few studies have reported the potential relationship between mitochondrial pyruvate carrier (MPC1) and inflammation, fibrosis, and insulin sensitivity in obese or NASH mouse… read more here.
Keywords: acid synthase; pyruvate carrier; lactylation; mitochondrial pyruvate ... See more keywords
Mitochondrial pyruvate carrier 1: a novel prognostic biomarker that predicts favourable patient survival in cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-01996-8
Abstract: Mitochondrial pyruvate carrier 1 (MPC1) is a key metabolic protein that regulates the transport of pyruvate into the mitochondrial inner membrane. MPC1 deficiency may cause metabolic reprogramming. However, whether and how MPC1 controls mitochondrial oxidative… read more here.
Keywords: cancer; mpc1 expression; mitochondrial pyruvate; mpc1 ... See more keywords