LncRNA X Inactive Specific Transcript Exerts a Protective Effect on High Glucose-Induced Podocytes by Promoting the Podocyte Autophagy via miR-30d-5p/BECN-1 Axis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Endocrinology"
DOI: 10.1155/2023/3187846
Abstract: Inhibiting podocyte autophagy promotes the development of diabetic nephropathy (DN). This study aims to explore the upstream regulatory mechanism of the autophagy-related gene BECN1 in high glucose (HG)-induced podocytes. C57BL/6 mice were treated with 50 mg/kg… read more here.
Keywords: mir 30d; high glucose; mpc5 cells; podocyte autophagy ... See more keywords
Shenqi granule upregulates CD2AP and α-actinin4 and activates autophagy through regulation of mTOR/ULK1 pathway in MPC5 cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.2139/ssrn.4229802
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE The incidence of membranous nephropathy (MN) continues to rise globally. Shenqi granule (SQ), composed of thirteen Chinese medicinal herbs, has clinical efficacy in the treatment of MN and has been used in China… read more here.
Keywords: mpc5 cells; expression; granule; mtor ... See more keywords
Cdc42 upregulation under high glucose induces podocyte apoptosis and impairs β-cell insulin secretion
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.905703
Abstract: Objectives The progressive impairment of β-cell function results in prolonged deterioration in patients with type 2 diabetes mellitus (T2DM). Interestingly, the finding on pancreatitis secondary to renal injury suggests that potential communication exists between kidney… read more here.
Keywords: cdc42; mpc5 cells; apoptosis; insulin secretion ... See more keywords