Poly(L-Glutamic Acid)-Drug Conjugates for Chemo- and Photodynamic Combination Therapy.
Sign Up to like & getrecommendations! Published in 2020 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202000192
Abstract: Despite the polymeric vascular disrupting agent (poly(L -glutamic acid)-graft-methoxy poly(ethylene glycol)/combretastatin A4) nanoparticles can efficiently inhibit cancer growth, their further application is still a challenge owing to the tumor recurrence and metastasis after treatment. In… read more here.
Keywords: combination; poly glutamic; glutamic acid; mpeg ... See more keywords
Silver Metallic Cyclodextrin-Core Star mPEG.
Sign Up to like & getrecommendations! Published in 2018 at "Macromolecular rapid communications"
DOI: 10.1002/marc.201800562
Abstract: A novel silver metallic β-cyclodextrin (β-CD)-core star methoxypolyethylene glycol (mPEG) (SM-CD-SPEG) is presented. For this, a well-defined water-soluble β-CD-core star mPEG with aldehyde groups (CD-star(ald)PEG, III) is first designed and synthesized via the copper-catalyzed azide-alkyne… read more here.
Keywords: mpeg; silver metallic; core star; metallic cyclodextrin ... See more keywords
Covalently linked graphene oxide/reduced graphene oxide-methoxylether polyethylene glycol functionalised silica for scavenging of estrogen: Adsorption performance and mechanism.
Sign Up to like & getrecommendations! Published in 2019 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2019.125729
Abstract: Water pollution by pharmaceuticals is a global issue and its remediation is important. To overcome this, we synthesised super hydrophobic nanoporous 3-dimensional ordered nanomaterials with multi-functional binding chemistry for highly efficient adsorption of estrogen (17β-estradiol).… read more here.
Keywords: graphene oxide; adsorption; sba; mpeg ... See more keywords
Design, synthesis and performance evaluation of mPEG‐PR: A novel non‐absorbable marker
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2019.02.009
Abstract: &NA; The aim of the present study was to develop a new marker for correcting water flux in the in situ single‐pass intestinal perfusion (SPIP) model. The new marker was designed and synthesized based on… read more here.
Keywords: marker; mpeg; non absorbable; phenol red ... See more keywords
Preparation and anticancer activity evaluation of self-assembled paclitaxel conjugated MPEG-PCL micelles on 4T1 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Industrial and Engineering Chemistry"
DOI: 10.1016/j.jiec.2018.11.048
Abstract: Abstract In this study, we prepared self-assembled micelles with methoxy poly(ethylene glycol)-b-poly(e-caprolactone) (MPEG-PCL) for paclitaxel (PTX) delivery. MPEG-PCL was synthesized by ring-opening polymerization in which the hydroxyl group was substituted for a carboxyl group by… read more here.
Keywords: mpeg pcl; pcl ptx; self assembled; mpeg ... See more keywords
Thermo thickening behavior of MPEG-b-PCL grafted Poly(acrylic acid): A molecular insight
Sign Up to like & getrecommendations! Published in 2018 at "Polymer"
DOI: 10.1016/j.polymer.2018.06.031
Abstract: Abstract We report on the synthesis and characterization of a new thermothickening polymer (PAA-g-(MPEG-b-PCL)) based on the grafting of a block copolymer of mono methoxy poly (ethylene glycol)–b-poly (caprolactone) (MPEG-b-PCL) onto poly (acrylic acid) (PAA).… read more here.
Keywords: mpeg; poly acrylic; acrylic acid; thermo thickening ... See more keywords
Organometallic S-arylation Reagents for Rapid PEGylation of Biomolecules.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00280
Abstract: Bioconjugation techniques for biomolecule-polymer conjugation are numerous; however, slow kinetics and steric challenges generally necessitate excess reagents or long reaction times. Organometallic transformations are known to circumvent these issues; yet, harsh reaction conditions, incompatibility in… read more here.
Keywords: mpeg; chemistry; arylation reagents; organometallic arylation ... See more keywords
Engineering a High-Affinity Anti-Methoxy Poly(ethylene glycol) (mPEG) Antibody for Sensitive Immunosensing of mPEGylated Therapeutics and mPEG Molecules.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00416
Abstract: Sensitive quantification of methoxy poly(ethylene glycol) (mPEG)-conjugated therapeutics for pharmacokinetic determination is critical for mPEGylated drug development. However, sensitive measurement of low-molecular-weight (lmw) mPEG compounds remains challenging due to epitope competition between backbone-specific anti-PEG antibodies.… read more here.
Keywords: mpeg; poly ethylene; mpeg molecules; affinity ... See more keywords
Overcoming PEG─Protein Mutual Repulsion to Improve the Efficiency of PEGylation.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c01192
Abstract: Bioconjugation reactions, such as protein PEGylation, generally require excess reagents because of their inefficiency. Intriguingly, few reports have investigated the fundamental causes of this inefficiency. This study demonstrates that the excluded volume effect (EVE)─caused by… read more here.
Keywords: reactive mpeg; mpeg; mutual repulsion; pegylation ... See more keywords
Engineering an Fc-Fusion of a Capsule Degrading Enzyme for the Treatment of Anthrax.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00227
Abstract: Polymers of d-glutamic acid (PDGA) form the capsule of the highly virulent Ames strain of B. anthracis. PDGA is antiphagocytic and weakly immunogenic; it enables the bacteria to evade the innate immune responses. CapD is an… read more here.
Keywords: fusion; mpeg; thr 352; capds334c ... See more keywords
Macroporous chitosan/methoxypoly(ethylene glycol) based cryosponges with unique morphology for tissue engineering applications
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82484-x
Abstract: Three-dimensional porous scaffolds are widely employed in tissue engineering and regenerative medicine for their ability to carry bioactives and cells; and for their platform properties to allow for bridging-the-gap within an injured tissue. This study… read more here.
Keywords: tissue engineering; mpeg; tissue; cryosponges unique ... See more keywords