Methotrexate conjugated polymeric prodrug encapsulating gold nanoparticles for combined chemo/radiation therapies
Sign Up to like & getrecommendations! Published in 2024 at "Applied Organometallic Chemistry"
DOI: 10.1002/aoc.7468
Abstract: Among the potent anticancer agents, methotrexate (MTX) is very effective against many different types of cancer cells. Implementation of chemotherapy along with radiotherapy, known as synchronous chemoradiotherapy, can augment the treatment efficacy. In the present… read more here.
Keywords: cancer; gold nanoparticles; pcl mtx; mpeg pcl ... See more keywords
Application of mPEG‐PCL‐mPEG Micelles for Anti‐Zika Ribavirin Delivery
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medical Virology"
DOI: 10.1002/jmv.29952
Abstract: Nanoparticles are rapidly becoming the method of choice for a number of nanomedicine applications, especially drug delivery. Many current nanoparticle models for drug delivery include a metal base with a drug conjugated to its surface.… read more here.
Keywords: mpeg pcl; ribavirin; drug delivery; drug ... See more keywords
Efficiency of flubendazole-loaded mPEG-PCL nanoparticles: A promising formulation against the protoscoleces and cysts of Echinococcus granulosus.
Sign Up to like & getrecommendations! Published in 2018 at "Acta tropica"
DOI: 10.1016/j.actatropica.2018.08.010
Abstract: None of the existing drugs can effectively treat the human cystic echinococcosis. This study aimed to improve the efficacy of flubendazole (FLBZ) against the protoscoleces and cysts of Echinococcus granulosus by preparing polymeric FLBZ-loaded methoxy… read more here.
Keywords: pcl nanoparticles; protoscoleces cysts; mpeg pcl; loaded nanoparticles ... See more keywords
Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy
Sign Up to like & getrecommendations! Published in 2020 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2020.04.002
Abstract: The prevalence of skin cancer is rising along with the rapid population aging in recent years. Traditional therapies, such as surgical treatment, radiotherapy, chemotherapy, photodynamic therapy, and immunotherapy, may accompany serious side effects, limiting their… read more here.
Keywords: cancer; mpeg pcl; skin cancer;
Amphiphilic diblock copolymers inhibit the formation of encrustation on the surface of biodegradable ureteral stents in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2020.125667
Abstract: Abstract Ureteral stents have been used to treat a variety of urinary diseases for decades. However, the complication of encrustation often impedes its therapeutic effectiveness and service after indwelling in human body. In the present… read more here.
Keywords: vitro vivo; encrustation; placl; ureteral stents ... See more keywords
Methotrexate‐loaded biodegradable polymeric micelles for lymphoma therapy
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.12.025
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Drug resistance and recurrence are the main clinical challenges in chemotherapy of lymphoma. Methotrexate (MTX), especially high dose MTX (HD MTX), is extensively used to treat some aggressive… read more here.
Keywords: mtx loaded; high dose; drug; mpeg pcl ... See more keywords
Preparation and anticancer activity evaluation of self-assembled paclitaxel conjugated MPEG-PCL micelles on 4T1 cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Industrial and Engineering Chemistry"
DOI: 10.1016/j.jiec.2018.11.048
Abstract: Abstract In this study, we prepared self-assembled micelles with methoxy poly(ethylene glycol)-b-poly(e-caprolactone) (MPEG-PCL) for paclitaxel (PTX) delivery. MPEG-PCL was synthesized by ring-opening polymerization in which the hydroxyl group was substituted for a carboxyl group by… read more here.
Keywords: mpeg pcl; pcl ptx; self assembled; mpeg ... See more keywords
Thermo thickening behavior of MPEG-b-PCL grafted Poly(acrylic acid): A molecular insight
Sign Up to like & getrecommendations! Published in 2018 at "Polymer"
DOI: 10.1016/j.polymer.2018.06.031
Abstract: Abstract We report on the synthesis and characterization of a new thermothickening polymer (PAA-g-(MPEG-b-PCL)) based on the grafting of a block copolymer of mono methoxy poly (ethylene glycol)–b-poly (caprolactone) (MPEG-b-PCL) onto poly (acrylic acid) (PAA).… read more here.
Keywords: mpeg; poly acrylic; acrylic acid; thermo thickening ... See more keywords
mPEG-PCL modified Caffeic acid eye drops for endotoxin-induced uveitis treatment
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-94296-4
Abstract: The modulation of inflammatory mediators has emerged as a critical therapeutic strategy in uveitis management. Current nonsteroidal anti-inflammatory therapies face limitations due to systemic side effects. Caffeic acid (CA), a natural polyphenol with anti-inflammatory properties,… read more here.
Keywords: mpeg pcl; pcl modified; inflammatory; histopathology ... See more keywords
Synthesis, characterization, and kinetic release study of methotrexate loaded mPEG–PCL polymersomes for inhibition of MCF-7 breast cancer cell line
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2018.1425433
Abstract: Abstract In this study, we designed a polymersome system for the controlled release of methotrexate (MTX) as an anticancer drug with the objective of improving the loading efficiency of the drug in polymersomes as well… read more here.
Keywords: pcl polymersomes; pcl; mpeg pcl; mtx ... See more keywords
Study of anti-Toxoplasma gondii effect of mPEG–PCL copolymeric loaded with pyrimethamine, in vitro
Sign Up to like & getrecommendations! Published in 2025 at "AMB Express"
DOI: 10.1186/s13568-025-01876-8
Abstract: The discovery of new drugs with minimal toxicity is crucially important in the search for effective treatments for toxoplasmosis. The study aimed to assess the effectiveness of pyrimethamine-loaded mPEG–PCL copolymeric nanoparticles (mPEG–PCL–Pyr) against Toxoplasma gondii… read more here.
Keywords: pcl copolymeric; pyrimethamine; study; mpeg pcl ... See more keywords