Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity
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DOI: 10.1208/s12249-022-02427-1
Abstract: Pinocembrin (PCB) is 5,7-dihydroxyl flavanone and has multiple pharmacological activities, namely, anti-inflammation, anti-osteoporotic, and so on. However, low water solubility and bioavailability have hindered its application. Herein, we aimed to increase its bioavailability through preparation… read more here.
Keywords: polymer micelles; pcb; f127 mpeg; mpeg pdlla ... See more keywords
Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel
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DOI: 10.2147/ijn.s150196
Abstract: Purpose Polymeric micelles are attractive nanocarriers for tumor-targeted delivery of paclitaxel (PTX). High antitumor efficacy and low toxicity require that PTX mainly accumulated in tumors with little drug exposure to normal tissues. However, many PTX-loaded… read more here.
Keywords: delivery; ptx; mpeg pdlla; ptx cms ... See more keywords
mPEG-PDLLA Micelles Potentiate Docetaxel for Intraperitoneal Chemotherapy in Ovarian Cancer Peritoneal Metastasis
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DOI: 10.3389/fphar.2022.861938
Abstract: Ovarian cancer is the second most common cause of gynecological cancer death in women. It is usually diagnosed late and accompanied by peritoneal metastasis. For ovarian cancer with peritoneal metastasis, intraperitoneal (IP) chemotherapy can maintain… read more here.
Keywords: cancer peritoneal; mpeg pdlla; ovarian cancer; cancer ... See more keywords