Improving Plasma Stability and Bioavailability In Vivo of Gemcitabine Via Nanoparticles of mPEG-PLG-GEM Complexed with Calcium Phosphate
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Research"
DOI: 10.1007/s11095-018-2506-2
Abstract: PurposeDespite being widely used for the treatment of several solid tumors, Gemcitabine (GEM) exhibits several suboptimal pharmacokinetic properties. Therefore, the design of nanoparticle delivery systems is a promising strategy to enhance GEM pharmacokinetic properties.MethodsIn this… read more here.
Keywords: calcium; mpeg plg; gem; plg gem ... See more keywords
Co-delivery of gemcitabine and cisplatin via Poly (L-glutamic acid)-g-methoxy poly (ethylene glycol) micelle to improve the in vivo stability and antitumor effect.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical research"
DOI: 10.1007/s11095-021-03139-0
Abstract: PURPOSE The intention of the study was to co-delivery gemcitabine and cisplatin with totally different nature by prodrug and micelle strategy to improve its in vivo stability and antitumor effect. METHODS A prodrug of gemcitabine… read more here.
Keywords: gem; gemcitabine cisplatin; mpeg plg;