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   Articles with "mpfc" as a keyword



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Cannabinoid receptor type 1 antagonists alter aspects of risk/reward decision making independent of toluene-mediated effects.

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recommendations! Published in 2021 at "Psychopharmacology"

DOI: 10.1007/s00213-021-05914-8

Abstract: Drugs of abuse including cannabis and inhalants impair risk/reward decision making. Cannabis use is often concurrent with inhalant intoxication; yet, preclinical studies investigating the role of endocannabinoids in inhalant misuse are limited. To address this… read more here.

Keywords: toluene; risk reward; cb1r; mpfc ... See more keywords
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GABA content within medial prefrontal cortex predicts the variability of fronto-limbic effective connectivity

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recommendations! Published in 2017 at "Brain Structure and Function"

DOI: 10.1007/s00429-017-1399-x

Abstract: The amygdala-medial prefrontal cortex (mPFC) circuit plays a key role in social behavior. The amygdala and mPFC are bidirectionally connected, functionally and anatomically, via the uncinate fasciculus. Recent evidence suggests that GABA-ergic neurotransmission within the… read more here.

Keywords: amygdala mpfc; mpfc; effective connectivity; medial prefrontal ... See more keywords
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“Braking” the Prefrontal Cortex: The Role of Glucocorticoids and Interneurons in Stress Adaptation and Pathology

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recommendations! Published in 2019 at "Biological Psychiatry"

DOI: 10.1016/j.biopsych.2019.04.032

Abstract: The medial prefrontal cortex (mPFC) receives information regarding stimuli and appropriately orchestrates neurophysiological, autonomic, and behavioral responses to stress. The cellular and neurochemical heterogeneity of the mPFC and its projections are key to fine-tuning of… read more here.

Keywords: mpfc; adaptation pathology; pathology; stress ... See more keywords
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Stress-Induced Differential Regulation Leads to Decoupling of the Activity between mPFC and Amygdala

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recommendations! Published in 2017 at "Biophysical Journal"

DOI: 10.1016/j.bpj.2016.11.748

Abstract: Exposure to severe stress leads to the development of psychiatric disorders. Clinical studies have shown that three brain areas involved in learning and memory—the hippocampus, amygdala and medial prefrontal cortex (mPFC)—undergo distinct changes with stress… read more here.

Keywords: mpfc; fear expression; stress; amygdala ... See more keywords
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Cortical adrenoceptor expression, function and adaptation under conditions of cannabinoid receptor deletion

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recommendations! Published in 2017 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2017.03.010

Abstract: ABSTRACT A neurochemical target at which cannabinoids interact to have global effects on behavior is brain noradrenergic circuitry. Acute and repeated administration of a cannabinoid receptor synthetic agonist is capable of increasing multiple indices of… read more here.

Keywords: mpfc; agr adrenoceptor; cannabinoid receptor; expression ... See more keywords
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Hypoactivity of the lateral habenula contributes to negative symptoms and cognitive dysfunction of schizophrenia in rats

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recommendations! Published in 2019 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2019.05.005

Abstract: Dopaminergic (DAergic) hypofunction in the medial prefrontal cortex (mPFC) has been implicated in the negative and cognitive symptoms of schizophrenia and is regulated by serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN). The lateral… read more here.

Keywords: schizophrenia; negative cognitive; mpfc; symptoms schizophrenia ... See more keywords
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Voltammetric evidence for discrete serotonin circuits, linked to specific reuptake domains, in the mouse medial prefrontal cortex

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recommendations! Published in 2019 at "Neurochemistry International"

DOI: 10.1016/j.neuint.2018.07.004

Abstract: The medial prefrontal cortex (mPFC) is an important brain region, that controls a variety of behavioral and functional outputs. As an important step in characterizing mPFC functionality, in this paper we focus on chemically defining… read more here.

Keywords: mpfc; serotonin; specific reuptake; medial prefrontal ... See more keywords
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Opposite control of mesocortical and mesoaccumbal dopamine pathways by serotonin2B receptor blockade: Involvement of medial prefrontal cortex serotonin1A receptors

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recommendations! Published in 2017 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2017.04.001

Abstract: ABSTRACT Recent studies have shown that serotonin2B receptor (5‐HT2BR) antagonists exert opposite facilitatory and inhibitory effects on dopamine (DA) release in the medial prefrontal cortex (mPFC) and the nucleus accumbens (NAc), respectively, thereby leading to… read more here.

Keywords: serotonin2b receptor; mpfc; blockade; medial prefrontal ... See more keywords
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mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress

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recommendations! Published in 2021 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2020.108412

Abstract: Depression with comorbid anxiety or cognitive symptoms can vary in terms of symptoms, pathophysiology and antidepressant efficacy, but the underlying neurobiological mechanisms remain to be elucidated. Previous studies from our group and others have shown… read more here.

Keywords: mpfc; transmission; anxiety; gabaergic transmission ... See more keywords
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Deficits in cognitive flexibility induced by chronic unpredictable stress are associated with impaired glutamate neurotransmission in the rat medial prefrontal cortex

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recommendations! Published in 2017 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2017.01.017

Abstract: Deficits in cognitive flexibility, the ability to modify behavior in response to changes in the environment, contribute to the onset and maintenance of stress-related neuropsychiatric illnesses, such as depression. Cognitive flexibility depends on medial prefrontal… read more here.

Keywords: cus; mpfc; cognitive flexibility; stress ... See more keywords
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Sex Differences in the Temporal Neuromolecular and Synaptogenic Effects of the Rapid-acting Antidepressant Drug Ketamine in the Mouse Brain

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recommendations! Published in 2019 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2018.11.053

Abstract: Preclinical evidence suggests that ketamine's rapid and sustained antidepressant actions are due to the induction of synaptogenesis in the medial prefrontal cortex (mPFC) and the hippocampus (HIPP), two brain regions implicated in the pathophysiology of… read more here.

Keywords: mpfc; ketamine; drug; sex ... See more keywords