Computational models for the classification of mPGES-1 inhibitors with fingerprint descriptors
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Diversity"
DOI: 10.1007/s11030-017-9743-x
Abstract: Human microsomal prostaglandin $$\hbox {E}_{2}$$E2 synthase (mPGES)-1 is a promising drug target for inflammation and other diseases with inflammatory symptoms. In this work, we built classification models which were able to classify mPGES-1 inhibitors into… read more here.
Keywords: fingerprint descriptors; classification; test set; mpges inhibitors ... See more keywords
Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation.
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DOI: 10.1016/j.ejmech.2017.12.059
Abstract: Inflammation comprises the reaction of the body to injury, in which a series of changes of the terminal vascular bed, blood, and connective tissue tends to eliminate the injurious agent and to repair the damaged… read more here.
Keywords: plant derived; inflammation; derived mpges; mpges inhibitors ... See more keywords
Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs
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DOI: 10.1038/s41598-018-23482-4
Abstract: Human mPGES-1 is recognized as a promising target for next generation of anti-inflammatory drugs without the side effects of currently available anti-inflammatory drugs, and various inhibitors have been reported in the literature. However, none of… read more here.
Keywords: anti inflammatory; generation anti; mpges inhibitors; wild type ... See more keywords
Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review
Sign Up to like & getrecommendations! Published in 2017 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2017.1344218
Abstract: ABSTRACT Introduction: Microsomal prostaglandin E2 synthase-1 (mPGES-1) catalyzes the terminal step of prostaglandin E2 (PGE2) generation. It is strongly upregulated in inflamed tissues and overexpressed in tumors and it has been recognized as a key… read more here.
Keywords: microsomal prostaglandin; prostaglandin synthase; inflammatory; mpges inhibitors ... See more keywords