Concomitant and noncanonical JAK2 and MPL mutations in JAK2V617F‐ and MPLW515 L‐positive myelofibrosis
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DOI: 10.1002/gcc.22781
Abstract: Sequential genotyping for phenotype‐driver mutations in JAK2 (exon 14), CALR (exon 9), and MPL (exon 10) is recommended in patients with myeloproliferative neoplasms. Yet, atypical JAK2‐ and MPL‐mutations were described in some triple‐negative patients. Whether… read more here.
Keywords: mpl mutations; jak2 mpl; noncanonical jak2; mpl ... See more keywords
Clinical and molecular characteristics of acute myeloid leukemia with MPL mutation
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DOI: 10.1080/16078454.2022.2066244
Abstract: ABSTRACT Objectives The current study aimed to explore the incidence of MPL mutations and the clinical and molecular characteristics of AML with MPL mutation. Methods In total, 1509 patients with newly diagnosed AML were retrospectively… read more here.
Keywords: mpl mutations; mpl; molecular characteristics; clinical molecular ... See more keywords
Primary myelofibrosis with concurrent CALR and MPL mutations: A case report
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DOI: 10.12998/wjcc.v8.i22.5618
Abstract: BACKGROUND Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by recurrent mutations in the JAK2, CALR, and MPL genes. The CALR and MPL co-mutation is very rare. To our knowledge, no more than five… read more here.
Keywords: mpl mutations; calr mpl; primary myelofibrosis; case ... See more keywords