Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease
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DOI: 10.1038/s41375-024-02219-5
Abstract: Thrombopoietin (Tpo), which binds to its specific receptor, the Mpl protein, is the major cytokine regulator of megakaryopoiesis and circulating platelet number. Tpo binding to Mpl triggers activation of Janus kinase 2 (Jak2) and phosphorylation… read more here.
Keywords: tyrosine residues; differential vivo; mpl y599; mpl ... See more keywords