Characteristics of myeloproliferative neoplasms in patients exposed to ionizing radiation following the Chernobyl nuclear accident
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DOI: 10.1002/ajh.25307
Abstract: Myeloproliferative neoplasms (MPNs) driver mutations are usually found in JAK2, MPL, and CALR genes; however, 10%‐15% of cases are triple negative (TN). A previous study showed lower rate of JAK2 V617F in primary myelofibrosis patients… read more here.
Keywords: patients exposed; ionizing radiation; rate; mpn patients ... See more keywords
Thromboses and hemorrhages are common in MPN patients with high JAK2V617F allele burden
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DOI: 10.1007/s00277-017-3040-8
Abstract: The most common causes of morbidity and mortality in myeloproliferative neoplasms (MPN) are thrombotic and hemorrhagic complications. The JAK2V617F mutation, commonly found in MPN, correlates with several clinical and laboratory characteristics even if the relevance… read more here.
Keywords: jak2v617f allele; allele burden; mpn patients;
Frequency of infections in 948 MPN patients: a prospective multicenter patient-reported pilot study
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DOI: 10.1038/s41375-020-0890-1
Abstract: Recently, several studies have reported on immunosuppression and infectious complications in patients with myeloproliferative neoplasms (MPN) receiving Janus kinase (JAK) inhibitor therapy (reviewed in [1]). These datasets included analyses of large multicenter trials comparing JAK… read more here.
Keywords: multicenter; pilot study; mpn; mpn patients ... See more keywords
Investigating the Role of the Gut Microbiome in the Inflammatory State of Myeloproliferative Neoplasms
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DOI: 10.1182/blood-2018-99-109761
Abstract: The human microbiome is composed of trillions of micro-organisms living in symbiosis with the human body. The interest in the microbiome and the clinical impact of its disruption (dysbiosis) has grown exponentially in the past… read more here.
Keywords: mpn; symptom burden; inflammatory; mpn patients ... See more keywords
SLAMF7high CD16negative Monocytes Increase in Peripheral Blood of Patients with Myelofibrosis in Correlation with JAK2V617F Mutation
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DOI: 10.1182/blood-2018-99-110916
Abstract: Introduction Myelofibrosis (MF) occurrence can be attributed to various pathogenic mechanisms. A recent study showed that the neoplastic clone of fibrocytes (spindle shaped, fibroblast-like blood cells derived from monocyte lineage) was essential in primary MF… read more here.
Keywords: cd16; jak2v617f; mpn patients; research funding ... See more keywords
Risk Factors for Secondary Cancer in a Case-Control Study on 1,259 Patients with Myeloproliferative Neoplasms
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DOI: 10.1182/blood-2018-99-112387
Abstract: INTRODUCTION The incidence of secondary cancer (SC) in patients with myeloproliferative neoplasms (MPN) is high and comparable to that of thrombosis. However, the identification of patient subgroups that might be at increased susceptibility of developing… read more here.
Keywords: risk; diagnosis; mpn patients; cancer ... See more keywords
The Pro-Adhesive and Reduced Angiogenic Properties of Endothelial Colony Forming Cells (ECFC) from JAK2V617F MPN Patients Are Not Related to the Expression of the JAK2 mutation in These Cells: A Potential Role of ADAM17
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-131488
Abstract: INTRODUCTION: JAK2V617F mutation is independently associated with a higher risk of venous thromboembolic events (VTE) in myeloproliferative neoplasms (MPN). We have previously shown that endothelial colony-forming cells (ECFCs) from JAK2V617F MPN patients do not express… read more here.
Keywords: jak2v617f mpn; mpn; expression; mpn patients ... See more keywords
Hydroxyurea Reduces Neutrophil Extracellular Trap Formation in Myeloproliferative Neoplasms
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DOI: 10.1182/blood-2020-139368
Abstract: Introduction: Ph-negative myeloproliferative neoplasms (MPNs) are a group of clonal stem-cell disorders with an elevated risk for thrombosis. Leukocytosis is a well-known risk factor for thrombosis. Neutrophils from MPN patients display features of activation. On… read more here.
Keywords: dna; treatment; time; mpn patients ... See more keywords
MPN patients with low mutant JAK2 allele burden show late expansion restricted to erythroid and megakaryocytic lineages.
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DOI: 10.1182/blood.2019002943
Abstract: 1Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland; 2Institute of Integrative Biology, Eidgenössische Technische Hochschule (ETH) Zürich, Zürich, Switzerland; 3Division of Hematology, University Hospital Basel, Basel, Switzerland; 4Clinic of Hematology, Clinical… read more here.
Keywords: hematology; patients low; university; mpn patients ... See more keywords
Immune Checkpoint Blockade Enhances Mutated Calreticulin-Induced T Cell Immunity in Myeloproliferative Neoplasms
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DOI: 10.1182/blood.v130.suppl_1.384.384
Abstract: Somatic mutations in the calreticulin (CALR) gene are key drivers of cellular transformation in myeloproliferative neoplasms (MPN) and are the second most common driver mutations in essential thrombocythemia (ET) and myelofibrosis (MF) patients. Each CALR… read more here.
Keywords: cell responses; mpn; mpn patients; cell ... See more keywords
Impaired Antibody Response Following the Second Dose of the BNT162b2 Vaccine in Patients With Myeloproliferative Neoplasms Receiving Ruxolitinib
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DOI: 10.3389/fmed.2022.826537
Abstract: Data on the effect of ruxolitinib on antibody response to severe acute respiratory coronavirus 2 (SARS-CoV-2) vaccination in patients with myeloproliferative neoplasms (MPN) is lacking. We prospectively evaluated anti-spike-receptor binding domain antibody (anti-S Ab) levels… read more here.
Keywords: ruxolitinib; mpn patients; receiving ruxolitinib; vaccine ... See more keywords