Evaluating the Effect of HDAC8 Inhibition in Malignant Peripheral Nerve Sheath Tumors.
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DOI: 10.1007/978-1-4939-6527-4_27
Abstract: Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive disease with a dismal prognosis. The disease can occur sporadically or in patients with inherited neurofibromatosis (NF-1). MPNST is typically resistant to therapeutic intervention. Hence,… read more here.
Keywords: malignant peripheral; inhibition; hdac8 inhibition; mpnst ... See more keywords
Synchronous Development of Multicentric Malignant Peripheral Nerve Sheath Tumors: Institutional Review.
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DOI: 10.1016/j.wneu.2018.12.088
Abstract: BACKGROUND Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue sarcomas, with approximately 50% occurring in patients diagnosed with neurofibromatosis type 1 (NF-1). NF-1 occurs in approximately 1/3000 individuals, and given that the lifetime… read more here.
Keywords: malignant peripheral; pathology; synchronous development; mpnst ... See more keywords
Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens
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DOI: 10.1093/ajcp/aqx060
Abstract: Objectives Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2… read more here.
Keywords: biopsy; malignant peripheral; loss; h3k27me3 ... See more keywords
Overcoming BET Inhibitor Resistance in Malignant Peripheral Nerve Sheath Tumors
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DOI: 10.1158/1078-0432.ccr-18-2437
Abstract: Purpose: BET bromodomain inhibitors have emerged as a promising therapy for numerous cancer types in preclinical studies, including neurofibromatosis type 1 (NF1)-associated malignant peripheral nerve sheath tumor (MPNST). However, potential mechanisms underlying resistance to these… read more here.
Keywords: bet; malignant peripheral; resistance; brd4 ... See more keywords
Factors Within the Endoneurial Microenvironment Act to Suppress Tumorigenesis of MPNST
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DOI: 10.3389/fncel.2018.00356
Abstract: Background: Deciphering avenues to adequately control malignancies in the peripheral nerve will reduce the need for current, largely-ineffective, standards of care which includes the use of invasive, nerve-damaging, resection surgery. By avoiding the need for… read more here.
Keywords: microenvironment; mpnst; factors within; within endoneurial ... See more keywords