Evaluating the Effect of HDAC8 Inhibition in Malignant Peripheral Nerve Sheath Tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6527-4_27
Abstract: Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive disease with a dismal prognosis. The disease can occur sporadically or in patients with inherited neurofibromatosis (NF-1). MPNST is typically resistant to therapeutic intervention. Hence,… read more here.
Keywords: malignant peripheral; inhibition; hdac8 inhibition; mpnst ... See more keywords
Synchronous Development of Multicentric Malignant Peripheral Nerve Sheath Tumors: Institutional Review.
Sign Up to like & getrecommendations! Published in 2018 at "World neurosurgery"
DOI: 10.1016/j.wneu.2018.12.088
Abstract: BACKGROUND Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue sarcomas, with approximately 50% occurring in patients diagnosed with neurofibromatosis type 1 (NF-1). NF-1 occurs in approximately 1/3000 individuals, and given that the lifetime… read more here.
Keywords: malignant peripheral; pathology; synchronous development; mpnst ... See more keywords
Profiling the cancer-prone microenvironment in a zebrafish model for MPNST
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DOI: 10.1038/s41388-024-03210-1
Abstract: Microenvironmental contributions to soft tissue sarcoma progression are relatively undefined, particularly during sarcoma onset. Use of animal models to reveal these contributions is impeded by difficulties in discriminating between microenvironmental, precancerous, and cancer cells, and… read more here.
Keywords: cancer; zebrafish model; microenvironment; microenvironmental precancerous ... See more keywords
The CoREST complex is a therapeutic vulnerability in malignant peripheral nerve sheath tumors
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-94517-w
Abstract: Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive sarcoma that may be seen in patients with neurofibromatosis type 1 (NF1) or occur sporadically. While surgery is the primary treatment for localized MPNST with… read more here.
Keywords: nerve sheath; mpnst; malignant peripheral; peripheral nerve ... See more keywords
Role of Histone H3K27 Trimethylation Loss as a Marker for Malignant Peripheral Nerve Sheath Tumor in Fine-Needle Aspiration and Small Biopsy Specimens
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqx060
Abstract: Objectives Accurate diagnosis of malignant peripheral nerve sheath tumor (MPNST) is often challenging on fine-needle aspiration (FNA) or core needle biopsy. Recurrent mutations in EED and SUZ12, which encode subunits of polycomb repressive complex 2… read more here.
Keywords: biopsy; malignant peripheral; loss; h3k27me3 ... See more keywords
BIOM-37. EXPLORING L-TYPE AMINO ACID TRANSPORTER 1 (LAT1) AS A DIAGNOSTIC MARKER AND THERAPEUTIC TARGET IN MALIGNANT PERIPHERAL NERVE SHEATH TUMORS (MPNST)
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0110
Abstract: Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that frequently arise from benign plexiform neurofibromas (PN). Approximately half of MPNST are associated with Neurofibromatosis type 1 (NF1). Despite partial elucidation of the… read more here.
Keywords: 18f fdopa; type; mpnst cells; lat1 ... See more keywords
EXTH-62. FOCAL ADHESION KINASE (FAK) IN CHROMOSOME 8 GAIN-ASSOCIATED MALIGNANT PERIPHERAL NERVE SHEATH TUMORS (MPNST)
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0992
Abstract: Malignant peripheral nerve sheath tumors (MPNST) are aggressive sarcomas often associated with Neurofibromatosis type 1 (NF1), a genetic syndrome driven by overactivation of the RAS pathway. MEK inhibitors (MEKi) target downstream components of the RAS… read more here.
Keywords: combination; malignant peripheral; meki; fak ... See more keywords
EXTH-26. Targeting Amino Acid Transporter in Malignant Peripheral Nerve Sheath Tumors: A Strategy to Enhance Efficacy of Chemotherapy and Targeted Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.1360
Abstract: Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas with limited treatment options and poor prognosis. Similar to other high-grade sarcomas, MPNSTs exhibit elevated metabolic demands and frequently upregulate nutrient transporters to support… read more here.
Keywords: treatment; efficacy; nerve sheath; mpnst ... See more keywords
Overcoming BET Inhibitor Resistance in Malignant Peripheral Nerve Sheath Tumors
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DOI: 10.1158/1078-0432.ccr-18-2437
Abstract: Purpose: BET bromodomain inhibitors have emerged as a promising therapy for numerous cancer types in preclinical studies, including neurofibromatosis type 1 (NF1)-associated malignant peripheral nerve sheath tumor (MPNST). However, potential mechanisms underlying resistance to these… read more here.
Keywords: bet; malignant peripheral; resistance; brd4 ... See more keywords
MEK Inhibitors Lead to PDGFR Pathway Upregulation and Sensitize Tumors to RAF Dimer Inhibitors in NF1-Deficient Malignant Peripheral Nerve Sheath Tumor
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DOI: 10.1158/1078-0432.ccr-24-1750
Abstract: Abstract Purpose: Malignant peripheral nerve sheath tumor (MPNST) is a highly aggressive subtype of soft-tissue sarcoma with a high propensity to metastasize and extremely limited treatment options. Loss of the RAS-GAP NF1 leads to sustained… read more here.
Keywords: combination; dimer inhibitors; raf dimer; mek ... See more keywords
Triple Combination of MEK, BET, and CDK Inhibitors Significantly Reduces Human Malignant Peripheral Nerve Sheath Tumors in Mouse Models
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-24-2807
Abstract: Abstract Purpose: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive soft-tissue sarcoma that develops sporadically or in patients with neurofibromatosis type 1 (NF1). Its development is marked by the inactivation of specific tumor suppressor… read more here.
Keywords: nerve sheath; mpnst; malignant peripheral; peripheral nerve ... See more keywords