PRC2 loss drives MPNST metastasis and matrix remodeling
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DOI: 10.1172/jci.insight.157502
Abstract: The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent loss-of-function mutations in PRC2 that are associated with poor outcome. Here, we identify a… read more here.
Keywords: prc2 loss; matrix remodeling; mpnst metastasis; loss ... See more keywords