Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson’s and Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Cell and Tissue Research"
DOI: 10.1007/s00441-017-2626-8
Abstract: Myeloperoxidase (MPO) is a key enzyme in inflammatory and degenerative processes, although conflicting reports have been presented concerning its expression in the brain. We studied the cellular localization of MPO and compared numbers of MPO… read more here.
Keywords: myeloperoxidase; immunoreactive cells; alzheimer disease; affected neurodegeneration ... See more keywords
Verdiperstat attenuates acute lung injury by modulating MPO/μ-calpain/β-catenin signaling.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2022.174940
Abstract: Verdiperstat, a myeloperoxidase (MPO) inhibitor, is a well-known drug used for the treatment of multisystem atrophy. However, its therapeutic effect on acute lung injury (ALI) remains to be elucidated. In this study, the effect of… read more here.
Keywords: catenin; acute lung; verdiperstat; injury ... See more keywords
Deglycosylation of myeloperoxidase uncovers its novel antigenicity.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.12.012
Abstract: Myeloperoxidase (MPO) is a common target antigen of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and is recognized in one-third of patients with anti-glomerular basement membrane (GBM) disease. Our previous study identified over 60% of patients with… read more here.
Keywords: myeloperoxidase; gbm disease; glycosylated mpo; mpo ... See more keywords
Quercetin Attenuates Vascular Endothelial Dysfunction in Atherosclerotic Mice by Inhibiting Myeloperoxidase and NADPH Oxidase Function.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00334
Abstract: Myeloperoxidase (MPO) exhibits a unique property to use H2O2 to oxidize chloride and lead to the generation of a strong oxidant, hypochlorous acid (HOCl), which plays important roles in atherosclerosis. A lot of evidence indicates… read more here.
Keywords: nadph oxidase; oxidase; mpo; endothelial dysfunction ... See more keywords
Inflammation Intensifies Monocrotaline-Induced Liver Injury.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07939
Abstract: Pyrrolizidine alkaloids (PAs) are the most common toxins of plant origin, and it is evident that PAs pollute soil, water, nearby plants, and derived foods. Cases of human poisoning due to ingestion of PA-contaminated foods… read more here.
Keywords: inflammation; liver injury; mct; mpo ... See more keywords
Synthesis and characterization of a bimetallic americium(III) pyrithionate coordination complex.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03352f
Abstract: The aqueous reaction of sodium pyrithione, (Na)mpo, with 243AmCl3·nH2O yields a dimerized complex, [243Am(mpo)2(μ-O-mpo)(H2O)]2·3H2O. This compound is compared with isostructural lanthanide pyrithionates, where dimerization across the 4f-block is observed to be dependent upon the size… read more here.
Keywords: americium iii; iii; mpo; bimetallic americium ... See more keywords
Myeloperoxidase Expression in B-Lymphoblastic Leukemia by Immunohistochemistry as a Diagnostic Confounder
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Clinical Pathology"
DOI: 10.1093/ajcp/aqaa137.000
Abstract: B-lymphoblastic leukemia (BLL) is a B lineage neoplasm that expresses typical immature B cell markers, but may also express myeloid-associated antigens. Myeloperoxidase (MPO) is a heme-containing peroxidase, which has been used as the single most… read more here.
Keywords: bll; pathology; mpo ihc; expression ... See more keywords
Myeloperoxidase causes both arrhythmogenic structural and electrical remodelling in neonatal rat ventricular myocyte monolayers
Sign Up to like & getrecommendations! Published in 2023 at "Europace"
DOI: 10.1093/europace/euad122.016
Abstract: Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): This study was supported by Netherlands Organization for Health Research and Development Background Myeloperoxidase (MPO), an enzyme most abundantly… read more here.
Keywords: ventricular myocyte; neonatal rat; control; mpo incubated ... See more keywords
Mild generalised pustular psoriasis patient with a heterozygous hypomorphic MPO variant successfully treated with granulocyte and monocyte adsorption apheresis.
Sign Up to like & getrecommendations! Published in 2023 at "Experimental dermatology"
DOI: 10.1111/exd.14846
Abstract: Pathogenic variants in MPO, which encodes the myeloperoxidase, were reported as causative genetic defects in several cases of generalised pustular psoriasis (GPP) in addition to patients with myeloperoxidase deficiency in 2020. However, which clinical subtypes… read more here.
Keywords: granulocyte monocyte; monocyte adsorption; generalised pustular; mpo ... See more keywords
A volatile sex attractant of tsetse flies
Sign Up to like & getrecommendations! Published in 2023 at "Science"
DOI: 10.1126/science.ade1877
Abstract: Tsetse flies transmit trypanosomes—parasites that cause devastating diseases in humans and livestock—across much of sub-Saharan Africa. Chemical communication through volatile pheromones is common among insects; however, it remains unknown if and how such chemical communication… read more here.
Keywords: tsetse; volatile sex; tsetse flies; mpo ... See more keywords
Recombinant Myeloperoxidase as a New Class of Antimicrobial Agents
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00522-21
Abstract: Over the past 2 decades, more than 20 new infectious diseases have emerged. Unfortunately, novel antimicrobial therapeutics are discovered at much lower rates. ABSTRACT Heme-containing peroxidases are widely distributed in the animal and plant kingdoms… read more here.
Keywords: new class; spectrum; mpo; rmpo ... See more keywords