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   Articles with "mpp induced" as a keyword



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LINC00667 regulates MPP+‐induced neuronal injury in Parkinson’s disease

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recommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.51480

Abstract: Parkinson’s disease (PD), also known as paralysis tremor, is a chronic disease of the central nervous system. It has been reported that hepatocyte nuclear factor 4 alpha (HNF4A) is upregulated in PD, but its specific… read more here.

Keywords: mpp induced; parkinson disease; linc00667 regulates; parkinson ... See more keywords
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Salidroside protected against MPP+‐induced Parkinson's disease in PC12 cells by inhibiting inflammation, oxidative stress and cell apoptosis

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recommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"

DOI: 10.1002/bab.1719

Abstract: The present study aimed to investigate the protective effects of salidroside (SAL) on 1‐methyl‐4‐phenylpyridinium (MPP+)‐induced PC12 cell model for Parkinson's disease. PC12 cells were pretreated with SAL in different concentrations and then exposed to MPP+.… read more here.

Keywords: mpp induced; pc12 cells; apoptosis; parkinson disease ... See more keywords
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LINC00943 acts as miR-338-3p sponge to promote MPP+-induced SK-N-SH cell injury by directly targeting SP1 in Parkinson’s disease

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recommendations! Published in 2022 at "Brain Research"

DOI: 10.1016/j.brainres.2022.147814

Abstract: BACKGROUND Abnormal expression of long non-coding RNA (lncRNA) is associated with the progression of Parkinson's disease (PD). LINC00943 has been proved to play an important role in the development of PD, so its role and… read more here.

Keywords: cell injury; sp1; mpp; mir 338 ... See more keywords
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Polysulfide protects midbrain dopaminergic neurons from MPP+-induced degeneration via enhancement of glutathione biosynthesis.

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recommendations! Published in 2018 at "Journal of pharmacological sciences"

DOI: 10.1016/j.jphs.2018.04.004

Abstract: Polysulfides are endogenous sulfur-containing molecular species that may regulate various cellular functions. Here we examined the effect of polysulfides exogenously applied to rat midbrain slice cultures, to address their potential neuroprotective actions. Na2S3 at concentrations… read more here.

Keywords: mpp induced; glutathione biosynthesis; effect; dopaminergic neurons ... See more keywords
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Inhibition of phosphodiesterase 4 by FCPR16 protects SH-SY5Y cells against MPP+-induced decline of mitochondrial membrane potential and oxidative stress

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recommendations! Published in 2018 at "Redox Biology"

DOI: 10.1016/j.redox.2018.02.008

Abstract: Phosphodiesterase 4 (PDE4) is a promising target for the treatment of Parkinson's disease (PD). However, the underlying mechanism has not yet been well elucidated. Additionally, most of current PDE4 inhibitors produce severe nausea and vomiting… read more here.

Keywords: mpp induced; fcpr16; mitochondrial membrane; membrane potential ... See more keywords
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Thioredoxin-1 mediates neuroprotection of Schisanhenol against MPP+-induced apoptosis via suppression of ASK1-P38-NF-κB pathway in SH-SY5Y cells

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-01000-3

Abstract: Oxidative stress-induced dopaminergic neuronal loss and apoptosis play a crucial role in the pathogenesis of Parkinson’s disease (PD), and as a vital antioxidant protein, thioredoxin (Trx) exerts neuroprotection against PD. In this study, we investigated… read more here.

Keywords: mpp induced; induced apoptosis; sy5y cells; apoptosis ... See more keywords
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MiR-19b alleviates MPP⁺-induced neuronal cytotoxicity via targeting the HAPLN4/MAPK pathway in SH-SY5Y cells

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recommendations! Published in 2018 at "RSC Advances"

DOI: 10.1039/c7ra13406a

Abstract: Background: miR-19b has been reported to be involved in nervous system disease including Parkinson's disease (PD). However its molecular basis has not been exhaustively elucidated. Materials and Methods: SH-SY5Y cells were treated with 1-methyl-4-phenylpyridinium (MPP+)… read more here.

Keywords: mpp induced; mir 19b; hapln4; sy5y cells ... See more keywords
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Retracted Article: LncRNA MALAT1 aggravates MPP-induced neuronal injury by regulating miR-212 in SH-SY5Y cells

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recommendations! Published in 2019 at "RSC Advances"

DOI: 10.1039/c8ra09260e

Abstract: Parkinson's disease (PD) is the most common neurodegenerative disease and its incidence is rising. read more here.

Keywords: aggravates mpp; retracted article; mpp induced; article lncrna ... See more keywords
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LncRNA SNHG15 mediates 1-methyl-4-phenylpyridinium (MPP+)-induced neuronal damage through targeting miR-29c-3p/SNCA axis

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recommendations! Published in 2022 at "Neurological Research"

DOI: 10.1080/01616412.2022.2129754

Abstract: ABSTRACT Background Parkinson’s disease (PD) is the most prevalent neurodegenerative disease in the elderly people. Long non-coding ribose nucleic acids (LncRNAs) can serve as molecular sponges for micro RNA (miRNA) and regulate gene expression, which… read more here.

Keywords: mpp induced; neuronal damage; mir 29c; 29c snca ... See more keywords
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Role of c-Abl-GSK3&bgr; Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction

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recommendations! Published in 2018 at "Toxicological Sciences"

DOI: 10.1093/toxsci/kfy155

Abstract: Impairment in autophagy-lysosomal pathway (ALP) results in accumulation of misfolded proteins and dysfunctional organelles, which is the hallmark of neurodegenerative diseases including Parkinson's disease (PD). Recent studies revealed activated nonreceptor tyrosine kinase Abelson (c-Abl) in… read more here.

Keywords: mpp induced; abl gsk3; autophagy lysosomal; gsk3 ... See more keywords
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Polygonatum sibiricum Polysaccharides Protect against MPP-Induced Neurotoxicity via the Akt/mTOR and Nrf2 Pathways

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recommendations! Published in 2021 at "Oxidative Medicine and Cellular Longevity"

DOI: 10.1155/2021/8843899

Abstract: Polygonatum sibiricum, a well-known life-prolonging tonic in Chinese medicine, has been widely used for nourishing nerves in the orient, but the underlying molecular mechanisms remain unclear. In this study, we found that P. sibiricum polysaccharides… read more here.

Keywords: mpp induced; medicine; sibiricum polysaccharides; akt mtor ... See more keywords