Association of mprF mutations with cross-resistance to daptomycin and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA)
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DOI: 10.1038/s41598-020-73108-x
Abstract: We first reported a phenomenon of cross-resistance to vancomycin (VCM) and daptomycin (DAP) in methicillin-resistant Staphylococcus aureus (MRSA) in 2006, but mechanisms underlying the cross-resistance remain incompletely understood. Here, we present a follow-up study aimed… read more here.
Keywords: cross resistance; vcm; mprf; resistance ... See more keywords
Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance
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DOI: 10.1128/mbio.01659-18
Abstract: Ever since daptomycin was introduced to the clinic, daptomycin-resistant isolates have been reported. In most cases, the resistant isolates harbor point mutations in MprF, which produces and flips the positively charged phospholipid LysPG. This has… read more here.
Keywords: mechanism; flippase; mprf; resistance ... See more keywords
MprF-mediated immune evasion is necessary for Lactiplantibacillus plantarum resilience in the Drosophila gut during inflammation
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DOI: 10.1371/journal.ppat.1012462
Abstract: Multiple peptide resistance factor (MprF) confers resistance to cationic antimicrobial peptides (AMPs) in several pathogens, thereby enabling evasion of the host immune response. The role of MprF in commensals remains, however, uncharacterized. To close this… read more here.
Keywords: mprf mediated; lactiplantibacillus plantarum; evasion; mprf mutant ... See more keywords