Association of mprF mutations with cross-resistance to daptomycin and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA)
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DOI: 10.1038/s41598-020-73108-x
Abstract: We first reported a phenomenon of cross-resistance to vancomycin (VCM) and daptomycin (DAP) in methicillin-resistant Staphylococcus aureus (MRSA) in 2006, but mechanisms underlying the cross-resistance remain incompletely understood. Here, we present a follow-up study aimed… read more here.
Keywords: cross resistance; vcm; mprf; resistance ... See more keywords
Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance
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DOI: 10.1128/mbio.01659-18
Abstract: Ever since daptomycin was introduced to the clinic, daptomycin-resistant isolates have been reported. In most cases, the resistant isolates harbor point mutations in MprF, which produces and flips the positively charged phospholipid LysPG. This has… read more here.
Keywords: mechanism; flippase; mprf; resistance ... See more keywords