Identification of Human Host Substrates of the SARS-CoV-2 Mpro and PLpro Using Subtiligase N-Terminomics
Sign Up to like & getrecommendations! Published in 2023 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.2c00458
Abstract: The recent emergence of SARS-CoV-2 in the human population has caused a global pandemic. The virus encodes two proteases, Mpro and PLpro, that are thought to play key roles in the suppression of host protein… read more here.
Keywords: mpro plpro; cov mpro; substrates sars; human host ... See more keywords
Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03090-9
Abstract: SARS-CoV-2 proteases Mpro and PLpro are promising targets for antiviral drug development. In this study, we present an antiviral screening strategy involving a novel in-cell protease assay, antiviral and biochemical activity assessments, as well as… read more here.
Keywords: cell protease; sars cov; protease; mpro plpro ... See more keywords