Inhibition of mitotic kinase Mps1 promotes cell death in neuroblastoma
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DOI: 10.1038/s41598-020-68829-y
Abstract: Neuroblastoma is the most common paediatric cancer type. Patients diagnosed with high-risk neuroblastoma have poor prognosis and occasionally tumours relapse. As a result, novel treatment strategies are needed for relapse and refractory neuroblastoma patients. Here,… read more here.
Keywords: mps1; mitotic kinase; neuroblastoma; inhibition ... See more keywords
TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability
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DOI: 10.1111/bph.13782
Abstract: Chromosomal instability is not only a hallmark of cancer but also an attractive therapeutic target. A diverse set of mitotic kinases maintains chromosomal stability. One of these is monopolar spindle 1 (Mps1, also known as… read more here.
Keywords: mps1; chromosomal instability; mps1 inhibitor; novel mps1 ... See more keywords
Structure-Aided Identification of an Inhibitor Targets Mps1 for the Management of Plant-Pathogenic Fungi
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DOI: 10.1128/mbio.02883-22
Abstract: M. oryzae is the causal agent of rice blast, one of the most devastating diseases of cultivated rice. Chemical control is still the main strategy for its management, and the identification of novel fungicide targets… read more here.
Keywords: aided identification; fungicide targets; identification; management ... See more keywords
Design, synthesis and biological evaluation of a new class of 7H-pyrrolo[2,3-d]pyrimidine derivatives as Mps1 inhibitors for the treatment of breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.2139/ssrn.4185504
Abstract: Monopolar spindle kinase 1 (Mps1), a core component of the spindle assembly checkpoint (SAC), plays a crucial role in the transition of cells from mid-to late mitosis. As an attractive therapeutic target, inhibition of Mps1… read more here.
Keywords: treatment; breast cancer; mps1 inhibitors; mps1 ... See more keywords
Monopolar Spindle 1 Kinase (MPS1/TTK) mRNA Expression is Associated with Earlier Development of Clinical Symptoms, Tumor Aggressiveness and Survival of Glioma Patients
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DOI: 10.3390/biomedicines8070192
Abstract: Inhibition of the protein kinase MPS1, a mitotic spindle-checkpoint regulator, reinforces the effects of multiple therapies against glioblastoma multiforme (GBM) in experimental settings. We analyzed MPS1 mRNA-expression in gliomas WHO grade II, III and in… read more here.
Keywords: mps1; mrna expression; tumor aggressiveness; tumor ... See more keywords